ORIGINAL ARTICLESVariation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquentsDeYoung, Colin G.a; Getchell, Maryab; Koposov, Roman A.g h; Yrigollen, Carolyn M.c; Haeffel, Gerald J.f; Klinteberg, Britt afj k; Oreland, Larsl; Ruchkin, Vladislav V.c m; Pakstis, Andrew J.e; Grigorenko, Elena L.c d i Author Information aDepartment of Psychology, University of Minnesota, Minnesota bSchool of Public Health, Harvard University, Massachusetts cChild Study Center dDepartment of Psychology, Yale University eDepartment of Genetics, Yale University School of Medicine, Connecticut fDepartment of Psychology, University of Notre Dame, Indiana, USA gCenter for Child and Adolescent Mental Health, University of Tromsø, Norway hInstitute of Psychology and Psychiatry, Northern State Medical University iDepartment of Psychology, Moscow State University, Russia jDepartment of Psychology, Stockholm University kCentre for Health Equity Studies, Karolinska Institute lDepartment of Neuroscience, Uppsala University mCentre for Violence Prevention, Karolinska Institute and Skonviks Psychiatric Clinic, Sweden Correspondence to Elena L. Grigorenko, PhD, Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06519, USA Tel: +203 737 2316; fax: +203 785 3002; e-mail: [email protected] Received 12 June 2008 Revised 25 August 2009 Accepted 13 September 2009 Psychiatric Genetics: February 2010 - Volume 20 - Issue 1 - p 20-24 doi: 10.1097/YPG.0b013e32833511e4 Buy Metrics Abstract Objective Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in populations with attention deficit/hyperactivity disorder (ADHD). This study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. In addition, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined. Method This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents. Results The Val allele of the Val158Met polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms. Conclusion The Val158Met polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population. © 2010 Lippincott Williams & Wilkins, Inc.