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High activity of Monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees

van der Vegt, Esther J.M.a; Oostra, Ben A.b; Arias-Vásquez, Alejandroc; van der Ende, Jana; Verhulst, Frank C.a; Tiemeier, Henninga c

doi: 10.1097/YPG.0b013e32832a5084

Individual differences in a functional polymorphism of the promoter of the Monoamine oxidase A (MAO-A) gene might partly explain the increased vulnerability of maltreated children for externalizing behaviour. A sample of 239 internationally adopted boys was studied. Adoptive parents provided the information about abuse and neglect before the adoption and rated externalizing behaviour of their adopted children, using the Child Behaviour Checklist. MAO-A alleles were classified in high and low activity. We found that individuals with high MAO-A activity had more externalizing behaviour than those with low MAO-A activity. No modifying effect of MAO-A on the relationship between early maltreatment on externalizing behaviour was observed. Our results suggest that in severely maltreated children, high MAO-A activity may not protect against the effects of maltreatment but may convey an increased risk for externalizing behaviour.

aDepartment of Child and Adolescent Psychiatry, Sophia Children's Hospital

Departments of bClinical Genetics

cEpidemiology, Erasmus MC, Rotterdam, The Netherlands

Correspondence to Dr Henning Tiemeier, MD, PhD, Erasmus MC-Sophia Children's Hospital, Department of Child and Adolescent Psychiatry, PO Box 2060, 3000 CB Rotterdam, The Netherlands


Received 23 December 2007 Revised 26 December 2008 Accepted 30 December 2008

© 2009 Lippincott Williams & Wilkins, Inc.