BRIEF REPORTSSequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorderZimprich, Alexandera; Hatala, Katharinaa; Riederer, Franza; Stogmann, Elisabetha; Aschauer, Harald N.b; Stamenkovic, Marab Author Information aDepartment of Neurology bDepartment of Psychiatry and Psychotherapy, Clinical Department of Biological Psychiatry, Medical University of Vienna, Austria Correspondence to Alexander Zimprich, Medical University of Vienna, Department of Neurology, Allgemeines Krankenhaus der Stadt Wien, Waehringer Guertel 18-20, Vienna A-1090, Austria Tel: +43 1 40 400 6349; fax: +43 1 40 400 3141; e-mail: [email protected] Received 6 August 2007 Revised 21 January 2008 Accepted 9 March 2008 Psychiatric Genetics: December 2008 - Volume 18 - Issue 6 - p 308-309 doi: 10.1097/YPG.0b013e3283060f6f Buy Metrics Abstract Mutations in the gene SLITRK1 (Slit and Trk-like 1) have been reported in patients with Tourette's disorder (TD). We sequenced the entire SLITRK1 gene including the coding region the 5′ and 3′ untranslated region in 92 Austrian patients with TD. No nucleotide changes within the protein-coding region were identified. One patient was found to carry a variant within the 3′ untranslated region (3383g>a), which was absent in 192 control individuals and which segregated in two additional family members with tic symptoms. In conclusion, our results provide no evidence for SLITRK1 playing a major role in TD. © 2008 Lippincott Williams & Wilkins, Inc.