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Linked gene ontology categories are novel and differ from associated gene ontology categories for the bipolar disorders

Newton, Joe R.

doi: 10.1097/YPG.0b013e328010f28c

Family, and twin genetic studies strongly indicate gene variants as predisposing to the bipolar disorders. Now, about 3000 genes are genetically linked and about 44 genes are genetically associated. Rank differences, however, exist between the linked gene Genetic ontology categories and the associated gene Genetic ontology categories. For the linked gene Genetic ontology categories, the activation of NF-κB-inducing kinase category is over-represented; in contrast, the associated genes show the Synaptic transmission category as over-represented. Association studies report selecting positional candidate genes from previous linkage studies, or, selecting genes on the basis of pathophysiologic hypotheses. Only a few of the pathophysiologic hypotheses genes, however, had been previously linked to the bipolar disorders. In particular, only a couple of the Synaptic transmission genes had been previously linked to bipolar disorders.

Correspondence and requests for reprints to Joe R Newton, 7005 E 540 Road, Claremore, OK 74019, USA

Tel: +1 918 266-1289; fax: +918 266 3457 e-mail:

Received 20 March 2006 Revised 14 July 2006 Accepted 9 August 2006

© 2007 Lippincott Williams & Wilkins, Inc.