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Reward dependence is related to norepinephrine transporter T-182C gene polymorphism in a Korean population

Ham, Byung-Jooa; Choi, Myoung-Jinb; Lee, Heon-Jeongb; Kang, Rhee-Hunb; Lee, Min-Soob


It is well established that approximately 50% of the variance in personality traits is genetic. The goal of this study was to investigate a relationship between personality traits and the T-182C polymorphism in the norepinephrine transporter gene. The participants included 115 healthy adults with no history of psychiatric disorders and other physical illness during the past 6 months. All participants were tested with the Temperament and Character Inventory and genotyped norepinephrine transporter gene polymorphism. Differences on the Temperament and Character Inventory dimensions among three groups were examined with one-way analysis of variance. Our study suggests that the norepinephrine transporter T-182C gene polymorphism is associated with reward dependence in Koreans, but the small number of study participants and their sex and age heterogeneity limits generalization of our results. Further studies are necessary with a larger number of homogeneous participants to confirm whether the norepinephrine transporter gene is related to personality traits.

aDepartment of Neuropsychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul

bDepartment of Psychiatry, Korea University College of Medicine, Seoul, Korea

Sponsorship: This work was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (KPGRN-R-04).

Correspondence and requests for reprints to Min-Soo Lee, M.D., Ph.D., Department of Psychiatry, Anam Hospital, Korea University College of Medicine, 126-1, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-705, Korea

Tel: +82 2 9205354; fax: +82 2 9233507;


Received 4 November 2003 Accepted 14 January 2004

© 2005 Lippincott Williams & Wilkins, Inc.