RESEARCH PAPERSAssociation study of oestrogen receptor α gene polymorphism and suicidal behaviours in major depressive disorderTsai, Shih-Jena b; Wang, Ying-Chiehc; Hong, Chen-Jeea b; Chiu, Hsien-Janeb cAuthor Information aDepartment of Psychiatry, Veterans General Hospital-Taipei, Taipei, Taiwan, ROC bSection of Psychiatry, National Yang-Ming University, Taipei, Taiwan, ROC cSection of Psychiatry, Yu-Li Veterans Hospital, Yuli, Taiwan, ROC Correspondence to Shih-Jen Tsai, M.D., Department of Psychiatry, Veterans General Hospital-Taipei, No. 201, Shih-Pai Road, Sec. 2, Taipei 11217, Taiwan, ROC. E-mail: [email protected] Received 31 August 2001 Accepted 20 May 2002 Psychiatric Genetics: March 2003 - Volume 13 - Issue 1 - p 19-22 Buy Abstract Objective Gender comparison in epidemiological studies has consistently demonstrated a greater prevalence for major depressive disorders (MDD) in females. Several lines of evidence have implicated oestrogen pathways in this gender difference. Furthermore, there is evidence that attempted suicides are more frequent in women. A population-based association study was used to test the hypothesis that the genetic variants (PvuII and XbaI polymorphisms) of the oestrogen receptor α gene (ER-α) confer susceptibility to MDD. Methods The ER-α was genotyped for 154 patients with MDD and 226 controls in a Chinese population. Results Statistical analysis showed a significant difference in the PvuII genotype and allele frequencies between the female MDD patients and the female controls (P=0.010 and P=0.004, respectively). However, no significant differences in ER-α genotype or allele frequencies were found between male MDD patients and male controls. Furthermore, the ER-α genotypes were not associated with suicide-attempt history for MDD cases. Conclusions Our results suggest that the ER-α may play a role in the susceptibility of MDD in females. Copyright © 2003 Wolters Kluwer Health, Inc. All rights reserved.