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Androgen receptor trinucleotide repeat polymorphism and personality traits

Jönsson, Erik G.a; von Gertten, Christinab; Gustavsson, J. Pettera,c; Yuan, Qiu-Pingb; Lindblad-Toh, Kerstinb; Forslund, Kaja; Rylander, Gunnara; Mattila-Evenden, Marjaa; Åsberg, Mariea; Schalling, Martinb

Research Papers

Human family and twin studies have established considerable heritable components influencing individual differences in personality traits as assessed by self-report questionnaires. We have investigated a trinucleotide repeat polymorphism in the androgen receptor gene and personality traits. Healthy Swedish subjects (n  = 335) were assessed with the Karolinska Scales of Personality inventory. There were tendencies (P  ≥ 0.006) in some scales indicating possible relationships between the androgen receptor allele length and personality traits related to dominance and aggression. However, after correction for multiple testing, no significant differences were found. We conclude that no significant association could be found between the androgen receptor polymorphism investigated and any personality trait, although the tendencies found are worthwhile subjects for replication attempts.

aDepartment of Clinical Neuroscience, Psychiatry Section, bDepartment of Molecular Medicine, Neurogenetics Unit, and cDepartment of Nursing, Karolinska Institute, Stockholm, Sweden

Correspondence to E.G. Jönsson, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, SE-171 76 Stockholm, Sweden. E-mail

Received 3 July 2000 accepted 13 March 2001

© 2001 Lippincott Williams & Wilkins, Inc.