Exonic variants of the GABAB receptor gene and panic disorder: PDF OnlyExonic variants of the GABAB receptor gene and panic disorderSand, P. G.a; Godau, C.a; Riederer, P.a; Peters, C.b; Franke, P.c; Nöthen, M. M.d; Stöber, G.a; Fritze, J.e; Maier, W.c; Propping, P.d; Lesch, KP.a; Riess, O.b; Sander, T.f; Beckmann, H.a; Deckert, J.a,gAuthor Information aDepartment of Psychiatry, University of Würzburg, Germany;bDepartment of Medical Genetics, University of Rostock, Germany;cDepartment of Psychiatry, anddDepartment of Human Genetics, University of Bonn, Germany;eDepartment of Psychiatry, University of Frankfurt, Germany;fDepartment of Neurology, Humboldt University of Berlin, Germany;gDepartment of Psychiatry, University of Münster, Germany Correspondence to Philipp G. Sand MD, Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Füchsleinstrasse 15, D-97080 Würzburg, Germany. E-mail:[email protected] Received 22 September 2000; accepted 8 January 2001 Psychiatric Genetics: December 2000 - Volume 10 - Issue 4 - p 191-194 Buy Abstract The enhancement of GABAergic neurotransmission has been closely linked to antipanic drug efficacy. This is the first study to investigate a putative association of exonic sequence variants of the human GABAB receptor 1 (GABABR1) gene and susceptibility to panic disorder. Three DNA sequence variants in exons 1a1, 7 and 11 were assessed by polymerase chain reaction-based restriction fragment length polymorphism in a case-control study among patients with panic disorder with and without agoraphobia (DSM III-R criteria) and blood donors. There was no indication of an increased vulnerability to panic disorder or agoraphobia with respect to the allelic variants under study. © 2000 Lippincott Williams & Wilkins, Inc.