BRIEF REPORTS: PDF OnlyAssociation of the neutral endopeptidase (MME) gene with anxietyComings, D. E.a; Dietz, G.a; Gade-Andavolu, R.a; Blake, H.a; Muhleman, D.a; Huss, M.b; Saucier, G.c; MacMurray, J. P.dAuthor Information aDepartment of Medical Genetics, City of Hope Medical Center, Duarte, CA, USA;bDepartment of Child and Adolescent Psychiatry, Charité-Virchow Humbolt-University, Berlin, Germany;cDepartment of Psychology, University of Oregon, Eugene, OR, USA;dDepartment of Psychiatry, Loma Linda University School of Medicine, Loma Linda, CA, USA Correspondence to David E. Comings, Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA. Tel: +1 626 359 8111, extn 2531, Fax: +1 626 301 8980; E-mail:[email protected] Received 28 February 2000; accepted 9 May 2000 Psychiatric Genetics: June 2000 - Volume 10 - Issue 2 - p 91-94 Buy Abstract Enkephalins have been implicated in the regulation of mood, anxiety, reward, euphoria and pain. One of the major enzymes for enkephalin degradation is neutral endopeptidase [enkephalinase, membrane metalloendopeptidase (MME)]. We identified a dinucleotide polymorphism in the 5′ region of theMMEgene. Subjects were placed into three genotypes, 3 / 3, 3 /x, andx / xsince the 3 allele was the most common of the six alleles. Using one-way analysis of variance, we examined the association of these genotypes with the mean SCL-90 scores for anxiety, depression, obsessive-compulsive and phobic anxiety symptoms in 120 Caucasian males from an addiction treatment unit. There was a significant association between theMMEgenotypes and the SCL-90 scores for phobic anxiety, obsessive-compulsive and anxiety at a Bonferroni corrected α value of 0.0125. These results support a role of genetic variants of enkephalin metabolism in anxiety. © 2000 Lippincott Williams & Wilkins, Inc.