Nutraceuticals, nutritional supplements, and the diet industry often provide misleading information, make faulty promises, and may also support profit over consumer safety. Furthermore, the U.S. Food and Drug Administration regulates dietary supplements as a food, not as a drug. As health care providers, we must be aware of current trends in supplements and nutrition programs so that we can screen our patients for contraindications to aesthetic treatments and educate and promote specific supplements/programs that are safe and evidence-based. Oxidative stress, chronic inflammation, and increased glycation can accelerate the aging process. The combination of an anti-inflammatory diet and pharmaceutical-grade nutritional supplements can impact the multiple forces involved in skin aging and help balance skin homeostasis. Using specific nutritional interventions and supplements can help repair damaged skin, improve skin health, and reduce skin senescence. Aesthetic providers can enhance healing and clinical results by educating patients and providing high-quality supplements that promote good aesthetic outcomes.