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Hyaluronidase: Understanding Its Properties and Clinical Application for Cosmetic Injection Adverse Events

Harrison, Jeanine BScN, MN, RN-EC, NP; Rhodes, Oriol RN, BAS, MBA

doi: 10.1097/PSN.0000000000000193
Departments: Aesthetic Department

The recent global consensus on the management of cosmetic aesthetic injectable complications from hyaluronic acid (HA) has increased the focus on the use of hyaluronidase more than ever before (M. Signorini et al., 2016). A comprehensive knowledge of facial anatomy, including structural positioning of facial arteries and veins, and an extensive knowledge of HA products available for injection procedures, combined with best practice protocols, will assist to prevent adverse events. Despite the growing number of patients using cosmetic fillers for facial restoration, the incidents incidence of adverse events remains low. Indeed, the avoidance of complications through safe and effective injection practice remains the key to preventing the need to use hyaluronidase.

Jeanine Harrison, BScN, MN, RN-EC, NP, is Nurse Practitioner, TH Medical Aesthetics, Thornhill, Ontario, Canada.

Oriol Rhodes RN, BAS, MBA, is Registered Nurse, TH Medical Aesthetics, Thornhill, Ontario, Canada.

Address correspondence to Jeanine Harrison, BScN, MN, RN-EC, NP, TH Medical Aesthetics, 8179 Yonge St, Thornhill, ON, L3T2C6, Canada (e-mail:

The author reports no conflicts of interest.

Copyright © 2017 by American Society of Plastic Surgical Nurses