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Breast: Case Report

Pyoderma Gangrenosum after Breast Cancer Resection: A Less-invasive and Early Treatment Using the Skin around Ulcers

Hirai, Kotaro MD*; Tsuge, Itaru MD, PhD*; Usui, Shunya MD; Takada, Masahiro MD, PhD; Yamanaka, Hiroki MD, PhD*; Katsube, Motoki MD, PhD*; Sakamoto, Michiharu MD, PhD*; Morimoto, Naoki MD, PhD*

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Plastic and Reconstructive Surgery - Global Open: February 2022 - Volume 10 - Issue 2 - p e4111
doi: 10.1097/GOX.0000000000004111
  • Open
  • SDC


Pyoderma gangrenosum (PG) is an uncommon ulcerative inflammatory skin disease characterized by a pathophysiological mechanism involving neutrophil dysfunction, but the detailed etiology is unclear.1 Surgical invasion is a risk factor, and 25% of postoperative PG cases reportedly occur after breast surgeries, including bilateral breast reduction (45%), breast reconstruction following cancer resection (25%), and lumpectomy or mastectomy (11%).2 Immunosuppressive therapy avoiding surgical debridement is the first-line treatment. After the gradual reduction of immunosuppression, negative-pressure wound therapy (NPWT) and skin grafting can be applied to cure the painful ulcers quickly.3 However, there are two issues to consider: the timing of skin grafting surgery and the risk of creating another ulcer at the skin donor site. We herein report a case of skin grafting under a surgical concept of less-invasive and short-term treatment.


An 82-year-old woman with a history of chronic renal failure with hemodialysis therapy was introduced to our plastic surgery team because of a high fever and severe pain of the breast wounds after bilateral breast cancer resection performed 12 days earlier (Fig. 1). The symptoms began from postoperative day 4 and worsened.

Fig. 1.:
Rapid development of painful bilateral ulcers along incision sites 12 days after breast cancer resection.

A physical examination revealed the following: blood pressure, 81/46 mm Hg; pulse, 63 beats/min; body temperature 37.3°C. A blood test showed the following: WBC, 22,740/µL; PLT, 199,000/µL; CRP, 16.7 mg/dL; CK, 8 U/L; Cre, 5.7 mg/dL. On the day of introduction, we performed emergency surgery under general anesthesia, resecting the edges of necrotic ulcers, including the strongly reddish skin and subcutaneous necrotic tissue, until we reached the surface of the muscular layer. (See figure, Supplemental Digital Content 1, which shows intraoperative findings of surgical debridement: the findings on day 18, 25 and 30 after debridement surgery, the findings on day 6, 13 and 34 after skin grafting surgery, and the postoperative findings at 6 months. The opened wounds were washed every day; however, a fever around 38°C persisted. All of the blood cultures and wound cultures, including the intraoperative samples, were negative, and a blood test on day 4 after debridement surgery showed WBC, 20,190/µL; PLT, 217,000/µL; CRP, 14.0 mg/dL; CK, 10 U/L; and Cre, 5.7 mg/dL. The clinical course differed markedly from those seen with the suspected bacterial infections and necrotizing soft tissue infections; therefore, we consulted dermatologists about the cause of the ulcers. They diagnosed the patient with PG because of the physical findings of characteristic painful, sterile ulcerations, bullae and pustules (Fig. 2), and pathological abundance of neutrophils in the absence of infection and vasculitis (See figure 2, Supplemental Digital Content 2, which shows histopathological examination [H&E] findings of massive neutrophil and inflammatory cell in the dermis. Scale bar: 100 µm. Oral administration of prednisolone 30 mg/day from day 10 after debridement surgery improved the symptoms of erythema and pain while reducing the discharge from wounds. We performed NPWT (V.A.C. Ulta; KCI, San Antonio, Tex.) with a negative pressure of 125 mm Hg and instillation and dwelling every 4 h from day 16 after debridement surgery. After gradually reducing the oral steroid intake to 12.5 mg/day, we planned to perform skin grafting surgery. (Supplemental Digital Content 1, (Supplemental Digital Content 2,

Fig. 2.:
The findings on day 9 after debridement surgery. The characteristic necrolytic ulcer with an irregular, violaceous and undermined border indicated pyoderma gangrenosum.

Two potential risks of surgical failure were of concern: (1) skin grafting failure because of the wound healing suppression induced by steroid intake, and (2) PG recurrence at the donor site, such as the abdominal or inguinal part. The patient’s bilateral breast wounds indeed showed thin, shiny, and smooth granulation, which made us predict the difficulty of stable engraftment even after NPWT (Supplemental Digital Content 1, Therefore, we planned to limit the surgical invasion by obtaining a skin graft from the breast region near the PG ulcer and by avoiding the use of tie-over sutures to fix the skin grafts.

Skin grafting surgery was performed on day 38 after debridement surgery. First, we performed suture closure while obtaining surplus skin from the right breast and lateral left breast wounds after wound bed preparation using NPWT for 3 weeks (Fig. 3A). The skin grafts from the bilateral breast were thinned from full-thickness into split-thickness skin grafts 0.025 inches using Padgett-Hood dermatome. The residual left breast wound was then covered by the split-thickness skin grafts, which were processed by mesh dermatome to make multiple drainage pores. Finally, the skin graft was positioned to the wound area using skin staplers and fixed by V.A.C. Ulta without using a tie-over suture dressing to reduce the damage to the skin around the ulcer (Fig. 3B).

Fig. 3.:
Intraoperative findings on day 38 after debridement surgery. Skin grafts were obtained from the right breast and lateral part of the left breast (A). Split-thickness skin grafts of 0.025 inches were fixed by NPWT (B).

The postoperative course was excellent (Supplemental Digital Content 1,, and she was discharged on day 74 after the first surgery for her breast cancer. Oral prednisolone intake was gradually reduced and ultimately finished two months after discharge. No recurrence of ulcers was detected for six months.


Treatment of PG can take a long time to complete because of the difficulty making a diagnosis and the need for low-invasiveness therapy with immunosuppressive therapy. A systematic literature review of PG after breast surgery indicated that complete wound healing took 5.1 months on average.4 Another systematic review showed a high skin grafting failure rate of 25% among cases of PG related to breast surgery; furthermore, the donor site of breast reconstruction resulted in abdominal PG ulcers in six cases.5

The key to successful short-term treatment is performing skin grafting surgery as early as possible; however, the risk of unsuccessful skin grafting and donor-site ulceration hamper surgeons’ decisiveness. We used surplus skin around the ulcers to avoid the risk of creating further ulcers, such as in the abdominal and inguinal areas. Evidence supporting the utility of NPWT for PG is accumulating,3,6,7 and Eisendle et al insisted that the best surgical approach is a split-thickness skin graft fixed with NPWT.8 We also performed NPWT for the preoperative wound bed preparation and postoperative skin graft fixation. Surgical invasion of suturing procedures is reported to exacerbate PG ulceration9; therefore, a strategy of not using tie-over suture fixation is a good approach.

Surgical reconstruction of PG is indeed challenging, as the treatment itself has the severe risk to induce pathergy.10 Moreover, medication such as corticosteroids and immunosuppressants decrease the success rate of split-thickness skin grafting.11 Our case showed thin, shiny, and smooth granulation even after 3-weeks NPWT under steroid medication. We recommend fail-safe surgical strategy in breast PG cases by minimizing the risk of creating new PG ulcers, which enables aggressive decision-making concerning skin grafting surgery and successful short-term treatment.


We performed short-term treatment with less-invasive skin grafting using NPWT and the skin around the breast ulcers as a donor. Minimizing the risk of another PG ulcer is essential in such cases.


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Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.