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Case Report

Unique Uses of SPY: Revision Rhinoplasty

Amirlak, Bardia MD; Dehdashtian, Amir MD, MPH*; Sanneic, Kyle MD; Lu, Karen B. MD; Cheng, Jonathan MD, FACS

Author Information
Plastic and Reconstructive Surgery - Global Open: June 2019 - Volume 7 - Issue 6 - p e2123
doi: 10.1097/GOX.0000000000002123
  • Open
  • United States


Tissue perfusion is vital to ensure an aesthetically pleasing and functional reconstructive surgery. Loss of skin flaps may lead to undesirable cosmetic outcomes, especially in the head and neck area. Early recognition of ischemic areas without delay is critical in correcting the compromised perfusion. Clinical exam remains the most commonly used method to assess tissue perfusion. Although widely acceptable, in challenging cases, it is often difficult to evaluate perfusion and additionally depends on a surgeon’s experience.1–3

In situations in which perfusion is questioned, surgeons may opt to reoperate to restore perfusion. But ultimately, these additional procedures may not be sufficient and result in tissue necrosis and poor cosmetic outcomes. Due to the limitations of clinical exams and the added complication of a reoperation, there is a need for new techniques to predict ischemic complications more precisely and objectively. The SPY Elite laser angiographic system (Stryker Corp/Novadaq Technologies, Kalamazoo, Mich.) is a unique technology to assess tissue perfusion via specific chemical properties of indocyanine green (ICG), a florescent agent with a short half-life of 3–4 minutes which is metabolized rapidly by liver. This safe method allows for real-time evaluation of perfusion objectively and has led to improved physician decision-making.3

Additionally, topical vasodilator agents have been recently used to manage ischemic conditions, due to their efficacy and convenience.2,4 In this case, we also used nitroglycerin paste to restore perfusion in a graft with high risk for ischemia.


Thirty-one-year-old male with history of a unilateral left cleft lip and associated nasal deformity presented 1 year after cleft lip revision and primary septorhinoplasty complaining of persistent nasal tip droop and mild tip asymmetry. The patient had initial cleft lip repair at 8 months of age following Alveolar Bone Graft at 10 years old. Primary septorhinoplasty was uneventful without any complications and it was accomplished by placing bilateral extended spreader grafts, alar rim grafts, alar onlay grafts, and columellar strut graft. Patient underwent secondary cleft rhinoplasty with use of costal cartilage for grafts. After reelevation of nasal skin and soft tissue, bilateral extended spreader grafts and a columellar strut were placed. Intradomal and transdomal tip modifying sutures were performed. There were no complications or major bleeding during the surgery and no artery was clipped. The skin was redraped over the nasal skeleton only to find a bluish color to the nasal tip and columella implicating tissue congestion (Fig. 1).

Fig. 1.
Fig. 1.:
A, During the surgery, the nasal tip begins to turn a bluish hue. B, Ischemia and hypoperfusion are confirmed by SPY angiography. Topical nitroglycerin was applied to the skin area of lower than 20% perfusion.

Intraoperative SPY imaging was performed confirming hypoperfusion. While in the operating room and before removing grafts, topical nitroglycerin was placed over the areas with perfusion of 20% or less. Twenty minutes later, repeated SPY imaging demonstrated adequate perfusion making it unnecessary to carve down tip grafts to decrease tension on the nasal skin at the expense of providing an optimal aesthetic result (Fig. 2). Topical nitroglycerin was continued for twice a day for 5 days and the nasal tip skin was fully viable 10 days postoperatively.

Fig. 2.
Fig. 2.:
A, Topical nitroglycerin was applied to hypoperfused area before removing the grafts. B, Repeat SPY angiography revealed adequate perfusion, enough to save the grafts.


Skin necrosis can be catastrophic complication in rhinoplasty. The use of SPY angiography in this case lead to a more informed decision, which prevented the patient from undergoing an additional unnecessary procedure.

The SPY Elite laser angiographic system targets the unique chemical feature of ICG. ICG was first described in 1957 and received FDA approval in 1959.5 The technology has been applied in reconstructive surgeries over the last decade.6 ICG is a contrast with minimal adverse reaction (approximate rate is 1 in 42,000 patients) even after multiple injections.3,6 This fluorescent dye is administered intravenously or intra-arterially, immediately binds to plasma proteins, and remains in circulation with minimal interstitial leakage. Maximum florescent effect occurs in near-infrared wavelengths, which penetrates the skin to visualize deep dermis and subcutaneous vasculature.3,7 ICG has a short half-life of 150–180 seconds making it suitable for multiple objective evaluation during the surgery. This information identifies ischemic complications and assists in the decision-making process as to when to take the patient back to the operating room versus planning for bedside pharmacologic interventions or even leech therapy.8 Nitroglycerin paste has a rapid dilatory effect on both arteries and veins and can be used to reestablish tissue perfusion. It has already been used to manage flap ischemia in surgeries.2,4

This case describes the application of topical nitroglycerin to salvage a hypoperfused nasal tip. SPY angiography changed the treatment plan of this patient, as the normal algorithm for tissue ischemia, in this setting, would be trimming or removing grafts in the hope of decreasing tension on the distal aspects of the skin and allowing for increased perfusion.9 This use of SPY angiography assisted the surgeons in evaluating the immediate effect of topical nitroglycerin. In this case, topical nitroglycerin was effective in alleviating the hypoperfusion and the use of SPY angiography in evaluating the nasal tip prevented the patient from removing the grafts or additional unnecessary surgeries and general anesthesia.

Nowadays, SPY angiography is available in most of the major facilities. In this recent case, the charges were covered by insurance. However, in cosmetic cases, the cost would come out of the facility fee or the surgeon’s fee which is low and extremely effective compared to the terrible outcome of nasal tip necrosis.

Based on the results of this case, cases involving secondary cleft rhinoplasty or multiple revision nasal surgery may benefit from SPY angiography to evaluate tissue perfusion in real time. Tenuous vasculature from multiple nasal surgeries can result in full tip necrosis during revision cases. The use of SPY angiography can assist surgeons in preoperative, intraoperative, and postoperative planning to minimize complications and risks.


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Copyright © 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.