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Closed Incision Negative Pressure Therapy in Oncological Breast Surgery: Comparison with Standard Care Dressings

Ferrando, Pietro M., MD, PhD*; Ala, Ada, MD; Bussone, Riccardo, MD; Bergamasco, Laura, PhD; Actis Perinetti, Federica, MD; Malan, Fabrizio, MD*

Plastic and Reconstructive Surgery – Global Open: June 2018 - Volume 6 - Issue 6 - p e1732
doi: 10.1097/GOX.0000000000001732
Original Article
Italy

Background: Negative pressure wound therapy was developed for treating wounds associated with unfavorable healing factors. The principles of the negative pressure wound therapy applied on clean and closed surgical incision originate the closed incision negative pressure therapy (ciNPT). We evaluated the use of ciNPT in the setting of oncological breast surgery.

Methods: From January 1, 2015, to June 31, 2015, we prospectively selected 37 patients undergoing oncological breast surgery with a minimum of 4 risk factors. Seventeen patients (25 surgeries) voluntary tested ciNPT (ciNPT sample), whereas the remaining 20 (22 surgeries) chose conventional postsurgery dressing (Standard Care sample). Follow-up controls to evaluate postsurgical complications were performed on days 7, 14, 30, and 90. At 12 months, the quality of life, scar, and overall aesthetic outcomes were evaluated with specific questionnaires filled in by surgeon and patient. The Standard Care sample was investigated on risk factors associated with poor healing.

Results: The ciNPT sample showed a significant prevalence of high risk factors, especially extensive undermining and bilateral surgeries, and a predominance of women under 65 years; only 1/25 (4%) surgical procedures was followed by complications. In the Standard Care sample, 10 of 22 surgeries (45%) were followed by complications. The difference in complication rate between the 2 samples was significant. The BIS (Body Image Scale) scores suggested that most patients were satisfied with their body image regardless of the type of dressing. All other questionnaire scores clearly vouched for a significant superiority of the ciNPT. Previous surgery ≤ 30 days emerged as the surgery-related high risk factor most frequently associated with postsurgery complications.

Conclusion: The results of our study support the use of ciNPT in oncological breast surgery: it showed to be a well-tolerated, adaptable, and reliable dressing capable of reducing postsurgical complications and improving scar outcomes in patients presenting with high risk factors.

From the *Plastic Surgery Department, Città della Salute e della Scienza, C.T.O. Hospital, Turin, Italy

Breast Surgery Department, Città della Salute e della Scienza, Sant’Anna Hospital, Turin, Italy

General Physics Department, University of Turin, Turin, Italy.

Published online 15 June 2018.

Received for publication October 16, 2017; accepted February 6, 2018.

Presented at the Italian Society of Plastic, Recosntructive and Aesthetic Surgery National Congress 2016 in Turin, Italy.

Statement of conforming to the Declaration of Helsinki: All patients signed an informed consent form before surgery, and the study was conducted in good clinical practice according to the Helsinki Declaration of 1975 and subsequent modifications.

Disclosure: The authors have no financial interest to declare in relation to the content of this article. The Article Processing Charge was paid for by the authors.

Pietro M. Ferrando, MD, PhD, Città della Salute e della Scienza di Torino, C.T.O. hospital, Via Gianfranco Zuretti, 29, 10126 Turin, Italy, E-mail: pmferrando@hotmail.it

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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INTRODUCTION

Oncologic breast surgery, employing techniques ranging from more conservative breast-conserving surgery (BCS) to intermediate oncoplastic surgery1–3 (OPS) to more radical ones (mastectomies, with or without tissue sparing and reconstructions), is an expanding and increasingly demanding field of surgery. The literature reports overall complication rates up to 35% for BCS cases,4 , 5 50% for breast reconstruction,6 , 7 and 30% for OPS.8 Postsurgical complications affect the quality of life, increase the costs of the health system, and may delay the beginning of adjuvant therapies.9

Negative pressure wound therapy was developed for treating wounds associated with unfavorable healing factors.10 It proved to be effective in the treatment of many chronic11 and surgical wounds,12 including breast surgery.13 The principles of the negative pressure wound therapy applied on clean and closed surgical incision originate the closed incision negative pressure therapy (ciNPT). A 2016 international consensus conference stated that the use of ciNPT in surgical procedures on high-risk patients appears to have the potential for reducing surgical incision complications and health care costs.14

In our institution, ciNPT with Prevena (KCI, an Acelity company, Sant Antonio, Tex.) is currently being used on abdominal wall reconstruction incisions of high-risk patients and on pathological scar revisions of severely burned patients, with good results in terms of suture dehiscence rate and scar features.15 Our hypothesis was that ciNPT with Prevena could give better results than the conventional dressing also in patients undergoing complex oncological breast surgeries and reconstructions. We thus performed a small-size study including the presurgery evaluation of patient- and surgery-related risk factors and the postsurgery estimation of wound complications and aesthetic outcomes. Our aim was to obtain an indication on 2 issues: (1) efficacy of ciNPT compared with Standard Care; (2) risk factors associated with a poor outcome in the Standard Care sample that could be considered strong advocates of the use of ciNPT.

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MATERIALS AND METHODS

Study Population

Our institution made available 25 Prevena to be tested in breast surgeries. The candidates for their application were drawn from the surgeries scheduled at our Breast Unit from January 1, 2015, to June 31, 2015.

The first step was an estimation of preoperative risk factors for each planned surgery. Risk factors, selected after a literature review, were divided between patient-related factors: age (≥ 65 years), body mass index (≥ 30 kg/m2), breast conformation (size, ptosis), smoking, diabetes, hypertension, use of corticosteroids, peripheral artery and liver diseases, neo-adjuvant/chemotherapy and radiation therapy; and surgery-related factors: previous surgery (≤ 30 days or > 30 days), extensive undermining (level-2 oncoplastic procedures, nipple-sparing mastectomy), type of reconstruction (1 or 2 stages implant-based reconstruction), use of acellular dermal matrices (ADM) and autologous reconstruction.16 , 17 Among these, obesity, large and ptotic breasts, smoking, radiation therapy, use of corticosteroids, previous surgeries within 30 days, extensive undermining, 1-stage reconstruction and use of ADM were to be considered at higher risk for complications.18 , 19 Based on a previously described grading system for the selection of patients for the use of Prevena in orthopedic surgeries,20 we set a threshold of a minimum of 4 risk factors (with at least 1 high risk).

Ineligibility criteria were: (1) documented allergy to acrylic glue, silver ionic, and polyester; (2) any type of surgical-site infection (SSI) as for the Antibiotic Prophylaxis for Preventing SSI Consensus Conference definition21 and antibiotics within 14 days of surgery.

Forty-seven surgical procedures satisfied all criteria. The patients involved were extensively informed about the different aspects of a ciNPT device, stressing that the postsurgical follow-up would have been the same independent of the dressing. Following the indication of our Ethical Committee, the choice was demanded to each patient, after consultation with her general practitioner.

The first 25 surgeries on patients who elected to be treated with Prevena constituted the ciNPT sample; the remaining 22 formed the Standard Care sample.

All patients signed an informed consent form, including a consent for the taking of image records, and the study was conducted in good clinical practice according to the Helsinki Declaration of 1975 and subsequent modifications.

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Postsurgery Protocol

All surgeries were performed by the same surgical team (general and plastic surgeon) employing the same techniques: BCS, OPS, tissue sparing (nipple-sparing and skin-sparing), and simple mastectomies were performed based on each patient’s oncological and reconstructive treatment goals.

The Prevena incision management system was placed on the closed surgical incision in a customized fashion (Customisable kit), providing a continuous −125 mm Hg pressure for 7 days. Following the Prevena removal, a skin adhesive closure (Steri-strip, 3M, St. Paul, Minn.) was applied over each incision for further 7 days. The drain(s) was(were) always left outside of the Prevena film, which secured the dressing to the application site (Fig. 1).

Fig. 1

Fig. 1

The standard care procedure involved Steri-strip skin adhesive closure for 14 days, changed after 7 days.

All other treatments were the same for the 2 groups: preoperative weight-based antibiotics with appropriate intraoperative redosing, ChloraPrep (CareFusion Corporation, San Diego, Calif.) skin prepping, and oral antibiotics continued postoperatively until drain(s) removal.

A team formed by a general surgeon, plastic surgeon, and breast nurse assessed the conditions of all patients on the follow-up visits (FU) on days 7, 14, 30, 90, and 12 months postoperatively.

The postsurgical complications evaluated were infection, hematoma, seroma, and skin necrosis. Infection was defined as: (1) purulent drainage from the incision; (2) positive culture swab; (3) signs or symptoms of systemic infection.22 , 23 Hematoma and seroma were considered only when aspiration was necessary. Skin necrosis was divided into minor, defined as partial-thickness skin flap necrosis requiring local wound management and major, defined as full-thickness skin flap necrosis requiring surgical intervention.24 Suction drains were removed once the output was less than 30 ml, not hematic over 24 hours.

The quality of life, scar, and overall aesthetic outcomes were evaluated with specific questionnaires filled in by surgeon and patient.

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Statistical Analysis

Continuous variables did not meet the normality requirements of the Shapiro-Wilks W test and were thus expressed as median (first and third quartiles) and compared with the nonparametric Mann-Whitney test.

Categorical variables were expressed as counts (percentages) and studied with the chi-square test with Yates correction, or, when appropriate, with Fisher’s exact test. The requirement for significance was P < 0.05. Calculations were run on Statplus:Mac version v6 (AnalystSoft, Walnut, Calif.) and on Openepi version 3.01.25

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RESULTS

Surgical Procedures Risk Factors

Table 1 shows the risk factors characterizing the surgical procedures in the 2 samples: ciNPT (25 surgeries on 17 patients) and Standard Care (22 surgeries on 20 patients).

Table 1

Table 1

The ciNPT sample shows a significant prevalence of high risk factors (P = 0.04), especially extensive undermining (P = 0.03) and bilateral surgeries (8 of 17 versus 2 of 20; P = 0.02), not to forget the age factor, with predominance of women under 65 years (88% versus 55%; P = 0.02), for whom the aesthetic issues are more important. Table 2 details the surgeries and reconstructions performed over the breasts in the two groups.

Table 2

Table 2

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Outcomes at Follow-up

At the 30 days FU, the postsurgery evolution was quite different for the 2 samples. In the ciNPT sample, only 1 of 25 (4%) surgical procedure was followed by complications: a seroma and a major skin necrosis. The patient, a 79-year-old woman with 3 high and 4 low risk factors underwent a partial thickness skin graft, and the wound was completely healed by the 90-days FU.

In the Standard Care group, 10 of 22 surgeries (45%) were followed by complications: 3 had 2 complications each (2 seroma and skin necrosis and 1 hematoma and skin necrosis), whereas 8 had 1 complication (4 skin necrosis, 3 seromas, and 1 hematoma). Four skin necrosis were major and underwent surgical closure, being completely healed by the 90 days FU; 3 were minor and were healed by secondary intention within 30 days.

The average Prevena placement time was 1 week. No adverse event such as blister formation, as reported by Howell et al.26 was observed.

The drain placement time was 17 (15–21) days for ciNPT and 19.5 (15–27) days for Standard Care (P = 0.70).

The difference in complication rate between the 2 samples was significant: 4% for ciNPT versus 45% for Standard Care (P = 0.001). Skin necrosis incidence was 1 of 25 (4%) in the ciNPT sample and 7 of 22 (32%) in the Standard Care group (P = 0.02).

At the 7 days FU, no adverse events, patient discomfort and ciNPT device and/or dressing malfunction were observed.

The quantitative evaluation of the postoperative body image and scar features was performed by means of questionnaires. The plastic surgeon filled in the Observer Scar Assessment Scale27 and the Manchester Scar Scale28. Two questionnaires on the personal level of satisfaction with the outcome were filled in by the patient: Body Image Scale (BIS)29 and Patient Scar Assessment Scale27. For all tests, the higher the scores, the lower the level of satisfaction and quality of the scar. The BIS scores suggested that most patients, whether treated with ciNPT or Standard Care, were satisfied with their body image. All other questionnaire scores clearly vouched for a significant superiority of the ciNPT postsurgery approach (Table 3).

Table 3

Table 3

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Risk Factors Associated with Complication in the Standard Care Sample

We investigated the Standard Care group for clues on the risk factors associated with poor healing. The comparison of surgeries with and without complications (10 and 12 cases, respectively) evidenced the significant role of the surgery-related high risk factors. Only 1 of the 12 cases without complications had 1 surgery-related high risk factor (extensive undermining), whereas 7 of the 10 cases with complications had at least 1 (8% versus 70%; P = 0.006). Two of the 7 cases were characterized by the overlapping of 3 high risks (extensive undermining, 1-stage reconstruction and ADM); the remaining 5 only by previous surgery within the last 30 days. Recent previous surgery thus emerged as the surgery-related high risk factor most frequently associated with postsurgery complications (5 of 10 versus 0 of 12; P = 0.01). Previous surgery ≤ 30 days was present also in the only patient in the ciNPT sample who presented a major skin necrosis. No difference was observed instead for the patient-related high risks (P = 0.92), in particular neither smoke (P = 0.86) nor radiation therapy (P ≥ 0.99).

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DISCUSSION

Preventing complications in oncological breast surgery can be achieved through the understanding of which factors may cause them. Some studies evaluated the risk factors associated with postsurgical complications in breast reconstruction.24 , 30 We were the first, to the best of our knowledge, to classify risk factors between patient- and surgery-related and to subclassify those considered to be at higher risk18 , 19 to obtain indications on when to use ciNPT in oncological breast surgeries.

The comparison of the postsurgery outcomes in the ciNPT sample (25 surgeries on 17 patients) and the Standard Care sample (22 surgeries on 20 patients) evidenced a significantly lower rate of complications for the former: 1 of 25 (4%) versus 10 of 22 (45%), P = 0.001. In particular, skin necrosis incidence was significantly lower for ciNPT sample than for Standard Care: 1 of 25 (4%) versus 7 of 22 (32%; P = 0.02). It is worth noticing that the number of high risk factors was significantly higher for ciNPT than for Standard Care (P = 0.04): P = 0.03 for extensive undermining and P = 0.02 for bilateral surgeries. This unbalance, penalizing ciNPT, lends more importance to the statistically significant better postsurgery outcome of this sample.

The significant difference in the rate of complications between the 2 samples cannot be attributed to a poor outcome of the Standard Care one: the postoperative complications and suture dehiscence rates observed in this group agree with those reported by Sullivan et al.31 for breast reconstruction and by Harvey et al.32 for OPS.

At the 1-year follow-up, the scar features were similar for the 2 groups. However, the questionnaires filled in by the plastic surgeon and those on the level of satisfaction with the outcome filled in by the patients clearly vouched for a significant superiority of the ciNPT postsurgery approach. This result agrees with other studies that examined the effect of ciNPT on the scar features and aesthetic outcome of the surgery.33–35

Our results on the positive effect of ciNPT are consistent with the latest literature on this subject. The first reports regard the ciNPT with PICO (Smith & Nephew Wound Management, London, United Kingdom). Pellino et al.36 reported a lower SSI rate in 25 patients undergoing breast surgery treated with ciNPT compared with the contralateral side with conventional dressing (8% versus 36%). Holt and Murphy37 reported a reduction in wound breakdown in 24 patient undergoing OPS treated with ciNPT, compared with the contralateral side where a reduction mammaplasty was performed (4.2% versus 16.7%).

Gabriel et al.38 were the first to report on the use of Prevena in 13 patients undergoing immediate postmastectomy breast reconstruction. They quoted an overall complication rate of 18% complications/breast, 12% suture dehiscence, and 4% flap necrosis. A direct comparison with our 4% complication rate is not straightforward. The number of risk factors per patients were higher in our study (4–7 versus 1–2), and some risk factors and surgical techniques in our study were associated with an increased transudate formation. This could explain our longer drain duration time (17 versus 8.2 days).

Kim et al.24 evaluated flap necrosis after immediate expander-based breast reconstruction, reporting an overall complication rate of 11% for ciNPT versus 28% for conventional dressing (P = 0.02) and an overall skin necrosis incidence of 9% versus 24% (P = 0.03). These figures well compare with our results: 4% versus 45% (P = 0.001) for the complication rate and 4% versus 32% (P = 0.02) for skin necrosis.

One of the outcome of our study was the greater impact of surgery-related risk factors over the patient-related risk factors: 8 of the 11 surgical procedures with complications had surgery-related high risks, against 13 of the 36 surgical procedures without complications, P = 0.04. Instead no difference for the patient-related high risks was observed. This result is consistent with the recommendation of the 2016 international consensus conference14 for patients undergoing high-risk procedures.

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CONCLUSIONS

The results of our study support the use of ciNPT in oncological breast surgery. It suffers from several limitations: it is underpowered to significantly identify all existing differences between the 2 samples, it was not a randomized case-control study and the patients in the 2 groups could not be stratified according to the risk factors.

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