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Abstract 21: Preoperative Versus Postoperative Language Specialization in Infants with Sagittal Craniosynostosis An ERP Study

Plastic and Reconstructive Surgery – Global Open: April 2016 - Volume 4 - Issue 4S - p 45
doi: 10.1097/
PRS PSRC Podium Proofs 2016

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Carolyn Chuang, BS,* Max Rolison, BS,* Jenny F. Yang, BS,* Eric D. Brooks, MD,* Peter W. Hashim, MD,† Roberto Travieso, MD,* Jordan Terner, MD,‡ Katherine K. Stavropoulos, PhD,* Derek M. Steinbacher, MD, DDS,* Nicole Landi, PhD,§ Linda C. Mayes, MD,* John A. Persing, MD,* James C. McPartland, PhD*

From the *Yale University School of Medicine, New Haven, Conn.; †Icahn School of Medicine at Mount Sinai, New York, N.Y.; ‡Montefiore Medical Center, Bronx, N.Y.; §University of Connecticut College of Liberal Arts and Sciences, Storrs, Conn.

PURPOSE: We compared perceptual narrowing, representative of language specialization, in infants with nonsyndromic sagittal craniosynostosis (NSC) preoperatively versus postoperatively using event-related potentials to measure impact of surgery on language processing. In refinement of our previous work, this assesses discrimination of native/nonnative speech instead of rudimentary response to general speech.

METHODS: Fifty infants (15 NSC and 35 control) completed an electroencephalogram (EEG) at age 3 to 6 months (presurgery); 33 infants (7 NSC and 26 control) completed a second EEG at age 12 to 14 months (postsurgery). During the EEG, infants listened to the dental /da/ and retroflex /da/ phonemes, present and not present in English, respectively. The mismatch negativity (MMN) event-related potential was extracted from EEG. Statistical analyses included t tests and repeated measures analysis of variance.

RESULTS: Preoperatively, there was a statistically significant (P = 0.01) difference in the MMN between the NSC versus control groups at the left frontal electrodes; the other regions showed no significant differences between groups (P > 0.05). Within groups, there was a significant effect of region within the left hemisphere of controls (frontal greater than central, P = 0.009), whereas in NSC, there was a significant effect of region within the right hemisphere (central greater than frontal, P = 0.015). Postoperatively, there was no significant difference in the MMN between the NSC versus control groups (P > 0.5) in all regions, and no significant within-group effects (P > 0.2) were observed.

CONCLUSIONS: There were significant differences in the MMN between NSC and control infants preoperatively but not postoperatively, which may suggest a more typical pattern of perceptual narrowing in NSC infants after surgery.

© 2016 American Society of Plastic Surgeons