PRS AAPS Oral Proofs 2016
Lin Fang, PhD, Luping Huang, PhD, MD
From the PeKing Union Medical College, Beijing, People's Republic of China.
PURPOSE: It was reported that IPL-induced melasma-like hyperpigmentation (MLH) would eventually lead to melasma. The study investigated the manifestation, influence factors, and preventive techniques of MLH.
METHODS: Six hundred seventy-five Asian patients with Fitzpatrick skin types III to IV treated with IPL were retrospectively studied.
RESULTS: Symmetric MLH was identified in 20 of 675 cases (2.96%; 2 male, 18 female). The mean age of 20 patients was 32.25 ± 5.79 years. The number of IPL treatment sessions was 2.20 ± 0.08. Twelve of the 20 cases were diagnosed as photoaging (60%) and 8 as freckles (40%). The pigmentary lesions of 14 of the 20 cases (70%), including 8 of the cases with prior photoaging and 6 with prior freckles, were characterized by multiple and widespread pigmentation with unclear edges and fusion trends that were diagnosed as “melasma trend” skin lesions. Six of the 20 cases with MLH (30%) had “strong” reactions after IPL treatment. Six (6/20, 30%) in the MLH group were not regular users of sunscreen. The non-MLH 655 subjects were aged from 15 to 65 years (mean, 34.48 ± 8.89 years), comprised 21 male and 634 female subjects, and had undergone 2.24 ± 0.13 IPL treatment sessions. Influence factors including freckles, “melasma trend” lesions, and strong post-IPL reactions were found to be statistically significant risk factors (P < 0.05).
CONCLUSIONS: MLH is an adverse event of IPL therapy in Asians. To avoid this complication, IPL users should be aware of the age, skin condition, and parameters setting of IPL.