DepartmentsHighly Reliable Case ManagementWhite, Charles William EdD, MBA, CPHQ; Alejandro, Jose PhD, RN-BC, MBA, CCM, FACHE, FAANAuthor Information Charles William White, EdD, MBA, CPHQ, is faculty in the College of Health and Human Development at California State University, Fullerton, CA, and faculty in the Health Professions Readiness program at El Centro College in Dallas, TX. He has extensive health care leadership and quality improvement experience. Jose Alejandro, PhD, RN-BC, MBA, CCM, FACHE, FAAN, is President of the Case Management Society of America (CMSA). Dr Alejandro is Assistant Professor at Mount St. Mary's University and is the Director of Case Management at UCI Health in Orange, CA. He was the 15th President (2012–2014) of the National Association of Hispanic Nurses. The editors report no conflicts of interest. Professional Case Management: May/June 2020 - Volume 25 - Issue 3 - p 107-110 doi: 10.1097/NCM.0000000000000431 Buy Metrics Abstract Health care is a highly complex system that is prone to error. Professional case managers across the continuum of care are key stakeholders who can significantly impact the effectiveness and efficiency of health care delivery at the individual and population health levels. This article explores how professional case managers can use evidence-based practice and generative knowledge to improve professional practice. In addition, the authors provide examples of how to actively support continuous change and high reliability within an organization. © 2020 Wolters Kluwer Health, Inc. All rights reserved.