ArticlesThe Application of Exposure Therapy and D-Cycloserine to the Treatment of Anorexia Nervosa: A Preliminary TrialSTEINGLASS, JOANNA, MD; SYSKO, ROBYN, MS; SCHEBENDACH, JANET, MA; BROFT, ALLEGRA, MD; STROBER, MICHAEL, PhD; WALSH, B. TIMOTHY, MDAuthor Information STEINGLASS, SCHEBENDACH, BROFT, and WALSH: College of Physicians & Surgeons of Columbia University, and New York State Psychiatric Institute; SYSKO: College of Physicians & Surgeons of Columbia University, New York State Psychiatric Institute, and Rutgers University; STROBER: Semel Institute of Neuroscience & Human Behavior, and Resnick UCLA Neuropsychiatric Hospital, David Geffen School of Medicine at UCLA Please send correspondence and reprint requests to: Joanna Steinglass, MD, Department of Psychiatry, Columbia University Medical Center/New York State Psychiatric Institute, 1051 Riverside Dr., Unit 98, New York, NY 10032. Results of this study were presented at the International Conference on Eating Disorders, June 9th, 2006, Barcelona, Spain, at the 158th meeting of the American Psychiatric Association, May 24th, 2005, Atlanta, GA, and the 39th meeting of the Association of Cognitive and Behavioral Therapies, November 18th, 2005, Washington, DC. This work was supported in part by the NIMH grants T32 MH15144 and MH65024. Journal of Psychiatric Practice®: July 2007 - Volume 13 - Issue 4 - p 238-245 doi: 10.1097/01.pra.0000281484.89075.a8 Buy SDC Metrics Abstract Objective. Novel approaches to the treatment of anorexia nervosa (AN) are needed. This preliminary study examined the utility and safety of an exposure therapy intervention and D-cycloserine (DCS) in a population of patients with AN. Method. Eleven participants completed a series of 6 laboratory meals, including pre- and post-exposure test meals and four exposure sessions. Participants were randomly assigned to receive either DCS or placebo in double-blind fashion before each of the 4 exposure sessions. These results were compared to data from a previously studied group of patients who received treatment as usual. Results. Total caloric intake increased significantly from the baseline meal session to the post-test meal session in the patients who received the exposure therapy intervention. Caloric intake did not increase significantly in the comparison group. Conclusion. These data suggest that an exposure therapy intervention specifically focused on meal consumption may be helpful in increasing intake of a test meal. Copyright © 2007 Wolters Kluwer Health, Inc. All rights reserved.