ColumnsDo Patients With Treatment-resistant Disorders Recover?Plakun, Eric M. MDAuthor Information PLAKUN: Medical Director/CEO, The Austen Riggs Center, Stockbridge, MA; and Founder, American Psychiatric Association Psychotherapy Caucus, Washington, DC The author declares no conflicts of interest. Please send correspondence to: Eric M. Plakun, MD, The Austen Riggs Center, 25 Main Street, Stockbridge, MA 01262 (e-mail: [email protected]). Journal of Psychiatric Practice: January 2022 - Volume 28 - Issue 1 - p 50-53 doi: 10.1097/PRA.0000000000000599 Buy Metrics Abstract This column describes the challenge posed by patients with treatment-resistant disorders. It then reviews a recently published study demonstrating that with adequate treatment and enough time—over a decade—even patients with conditions that were previously considered treatment-resistant and who have high degrees of comorbidity, suicide risk, and a significant number of prior hospitalizations can achieve full recovery in terms of measures of psychodynamic conflicts, symptoms, and overall functioning. These areas of improvement converge and thus appear to be linked, suggesting the transdiagnostic relevance of psychodynamic measures. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.