Clinical Case DiscussionsAnti-NMDA Receptor Encephalitis: A Challenge in Psychiatric SettingsKanniah, Guna MClinPharm, PG Cert Psychopharmacotherapy, M PSNZ; Kumar, Rishi MBChB; Subramaniam, Ganesh MBChBAuthor Information KANNIAH and SUBRAMANIAM: Mental Health and Addictions Services, Waikato Hospital, Hamilton, New Zealand KUMAR: Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand All identifying information has been removed/altered, and written consent was obtained from the patient for publication of this report. The authors declare no conflicts of interest. Please send correspondence to: Guna Kanniah, MClinPharm, PG Cert Psychopharmacotherapy, Senior Clinical Pharmacist, Mental Health and Addictions Services, Waikato Hospital, PO Box 3200, Hamilton 3204, New Zealand (e-mail: [email protected]). Journal of Psychiatric Practice: January 2022 - Volume 28 - Issue 1 - p 78-83 doi: 10.1097/PRA.0000000000000602 Buy Metrics Abstract Anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis is a condition that was only identified relatively recently. It often presents in psychiatric settings, with clinical presentations that may overlap with those of other psychiatric disorders such as psychoses secondary to schizophrenia, substance use, or brief delusional disorder. It often presents in women of child bearing age and has a relatively high mortality rate. The treatment approach for anti-NMDA receptor encephalitis is considerably different from that used for other psychiatric and neurological conditions. Early recognition, correct diagnosis, and appropriate management of the condition are of vital importance to the prognosis, including reducing mortality rate, admissions to intensive care units, recurrence, complications of the disease and in some cases, irreversible hippocampal damage. We present a case that highlights the typical presentation of anti-NMDA receptor encephalitis in a young woman and discuss management and outcome. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.