Clinical Case DiscussionsClinical Use of Prazosin in a Patient With Acute Stress Disorder: A Case ReportSRIVASTAVA, ANSHUMAN A. MD; OPLER, DOUGLAS J. MDAuthor Information SRIVASTAVA: Rutgers New Jersey Medical School, Newark, NJ OPLER: Department of Psychiatry, Rutgers New Jersey Medical School, Newark, NJ The authors declare no conflicts of interest. Please send correspondence to: Anshuman A. Srivastava, MD, Rutgers New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103 (e-mail: email@example.com). Journal of Psychiatric Practice: May 2020 - Volume 26 - Issue 3 - p 246-248 doi: 10.1097/PRA.0000000000000468 Buy Metrics Abstract Prazosin is an alpha-1 blocker that is commonly given to patients with posttraumatic stress disorder (PTSD) to reduce nightmares and flashbacks. Its use in acute stress disorder (ASD), however, has not been well characterized. There is a moderately positive correlation between ASD and the subsequent development of PTSD, which indicates that there may be some common neurobiological mechanisms that connect the 2 conditions. We present the case of a 51-year-old man who was experiencing symptoms of ASD following a motor vehicle accident that occurred a few days earlier. He was reporting flashbacks and nightmares of the accident, but after being treated with prazosin, his symptoms completely resolved. Prazosin may be effective in treating the symptoms of ASD and, by doing this, it may also play a role in inhibiting the progression of ASD to PTSD. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.