Delusional disorder is a relatively rare psychotic illness characterized by delusions with contents that are theoretically possible but highly unlikely, and an absence of the disorganized thought and negative symptoms characteristic of schizophrenia. The illness is rarely studied systematically and most guidance with regard to the treatment derives from case reports and small case series. Antipsychotic medications are the mainstay of treatment, but it is not clear whether any particular agent is more effective than others. We report the case of a patient with delusional disorder who had failed to respond to risperidone but improved markedly with aripiprazole. Aripiprazole may show promise as a treatment for delusional disorder, possibly as a result of its effects on both dopaminergic and serotonergic receptors.
IANNUZZI, PATEL, and STEWART: Department of Psychiatry, James A Haley VA Hospital, University of South Florida College of Medicine, Tampa, FL
The authors declare no conflicts of interest.
Please send correspondence to: Jonathan T. Stewart, MD, DLFAPA, AGSF, Professor in Psychiatry and Geriatric Medicine, Mental Health and Behavioral Sciences Service (116A), James A Haley VA Hospital, University of South Florida College of Medicine, 13000 Bruce B Downs Blvd, Tampa, FL 33612 (email: firstname.lastname@example.org).