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An Examination of Fluoxetine for the Treatment of Selective Mutism Using a Nonconcurrent Multiple-Baseline Single-Case Design Across 5 Cases

BARTERIAN, JUSTIN A. PhD; SANCHEZ, JOEL M. MD; MAGEN, JED DO, MS; SIROKY, ALLISON K. MA; MASH, BRITTANY L. MA; CARLSON, JOHN S. PhD

Journal of Psychiatric Practice®: January 2018 - Volume 24 - Issue 1 - p 2–14
doi: 10.1097/PRA.0000000000000284
Articles

This study examined the utility of fluoxetine in the treatment of 5 children, aged 5 to 14 years, diagnosed with selective mutism who also demonstrated symptoms of social anxiety. A nonconcurrent, randomized, multiple-baseline, single-case design with a single-blind placebo-controlled procedure was used. Parents and the study psychiatrist completed multiple methods of assessment including Direct Behavior Ratings and questionnaires. Treatment outcomes were evaluated by calculating effect sizes for each participant as an individual and for the participants as a group. Information regarding adverse effects with an emphasis on behavioral disinhibition and ratings of parental acceptance of the intervention was gathered. All 5 children experienced improvement in social anxiety, responsive speech, and spontaneous speech with medium to large effect sizes; however, children still met criteria for selective mutism at the end of the study. Adverse events were minimal, with only 2 children experiencing brief occurrences of minor behavioral disinhibition. Parents found the treatment highly acceptable.

BARTERIAN: Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH

SANCHEZ: The Right Door for Hope, Recovery and Wellness, Ionia, MI, and Wedgwood Christian Services, Grand Rapids, MI

MAGEN: Department of Psychiatry, Michigan State University, East Lansing, MI

SIROKY and CARLSON: Department of Counseling, Educational Psychology, & Special Education, Michigan State University, East Lansing, MI

MASH: Howell, MI

The authors declare no conflicts of interest.

Please send correspondence to: Justin A. Barterian, PhD, Department of Psychiatry and Behavioral Health, The Ohio State University, 291-C McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210 (e-mail: justin.barterian@osumc.edu).

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