Neurobiological Mediators of Squalor-dwelling BehaviorGUPTA, MANAN, MBBS; BISHNOI, RAM J., MBBS; SCHILLERSTROM, JASON E., MDJournal of Psychiatric Practice®: September 2017 - Volume 23 - Issue 5 - p 375–381 doi: 10.1097/PRA.0000000000000253 CLINICAL CASE DISCUSSIONS Buy Abstract Author InformationAuthors Article MetricsMetrics Squalor-dwelling behavior has been characterized as living in conditions so unsanitary that feelings of revulsion are elicited among visitors. This behavior is commonly associated with an insensitivity to distress/disgust and a failure to understand the direness of one’s living situation, which leads to social isolation and impairment in quality of life. Etiologically, several associations have been described in the literature, including age-related decline, lower socioeconomic status, and rural dwelling status. Primary neuropsychiatric disorders, such as psychosis, alcoholism, dementia, personality disorders, developmental delays, and learning or physical disabilities are frequently seen in squalor-dwelling individuals. However, none of these disorders seems to be necessary or sufficient to explain the behavior. Neurobiologically, squalor-dwelling behavior has been associated with frontal lobe dysfunction as evidenced by executive dysfunction; however, cognitive impairments also fail to completely explain this behavior. The purpose of this report is to describe a typical case of squalor-dwelling behavior and use it as an example to illustrate the complexity of uncovering the neurobiological basis for this maladaptive personal and public health threat. Neuroimaging findings from our case and a review of the literature point toward decreased activity in the insular cortex and the amygdala as a unifying biological explanation for squalor-dwelling behaviors. GUPTA, BISHNOI, and SCHILLERSTROM: Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX The authors declare no conflicts of interest. Please send correspondence to: Manan Gupta, MBBS, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229 (e-mail: firstname.lastname@example.org). Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.