CLINICAL CASE DISCUSSIONA Case of Capgras Syndrome Related to HypothyroidismHINES, AISHA DO; STEWART, JONATHAN T. MD; CATALANO, GLENN MDAuthor Information HINES: HealthLinkNow Inc., Sacramento, CA STEWART and CATALANO: James A Haley VA Hospital and Department of Psychiatry, University of South Florida College of Medicine, Tampa, FL The authors declare no conflicts of interest. Please send correspondence to: Jonathan T. Stewart, MD, Mental Health and Behavioral Sciences Service (116A), James A Haley VA Hospital, 13000 Bruce B Downs Blvd, Tampa, FL 33612 (e-mail: [email protected]). Journal of Psychiatric Practice: November 2015 - Volume 21 - Issue 6 - p 445-448 doi: 10.1097/PRA.0000000000000108 Buy Metrics Abstract Hypothyroidism is commonly associated with a variety of psychiatric conditions, most commonly depression and cognitive impairment, but up to 5% to 15% of symptomatically hypothyroid patients may develop a nonaffective psychosis, classically referred to as “myxedema madness.” We report the case of a woman who developed Capgras syndrome in the context of hypothyroidism, and whose psychosis rapidly resolved with levothyroxine supplementation. To date, very few cases of Capgras syndrome related to hypothyroidism have been reported. The pathophysiology of this condition remains unclear but it may be related to global cerebral hypometabolism or possibly to increased cerebral dopamine. Given the robust response of “myxedema madness” to thyroid replacement, psychiatrists should remain vigilant for covert hypothyroidism in patients with psychosis and atypical histories or presentations. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.