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Rates and Correlates of Nonadherence to Treatment in Obsessive-Compulsive Disorder


Journal of Psychiatric Practice®: January 2013 - Volume 19 - Issue 1 - p 42–53
doi: 10.1097/01.pra.0000426326.49396.97

The goal of this cross-sectional study was to identify the rates and correlates of treatment refusal and/or dropout in a treatment-seeking sample of patients with obsessive-compulsive disorder (OCD). Specifically, we investigated the relationships between treatment adherence and different OCD dimensions, intelligence, and insight into OCD. The study involved 60 patients with OCD who were being treated in a specialized university OCD clinic. The patients’ adherence to standard treatment was assessed with the Treatment Adherence Survey-Patient Version. Patients were also evaluated with the following instruments: the Mini-International Neuropsychiatric Interview 6.0, the Dimensional Yale-Brown ObsessiveCompulsive Scale-short version, the Brown Assessment of Beliefs Scale, the Beck Depression Inventory, the Sheehan Disability Scale, and the Wechsler Abbreviated Scale of Intelligence. The patients with OCD who refused to undertake CBT (46%) displayed greater rates of obsessions with aggressive/violent content. Among patients who started CBT (n=32), 51% withdrew before completing therapy. Patients who refused medication for OCD (52%) displayed greater severity of OCD (particularly hoarding), less insight into symptoms, and greater disability. Of the patients with OCD who were given drug therapy (n=58), 61% reported having taken their medication less frequently and/or at a smaller dose than prescribed or discontinuing the use of medication altogether. Treatment nonadherence is common among patients with OCD. This study found that aggressive/violent obsessions were associated with nonadherence to CBT, while greater severity of OCD (particularly hoarding) and poorer insight were associated with poorer adherence to drug therapy. Future research is needed to clarify whether these OCD phenotypes predict or are the consequence of treatment nonadherence.

Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil; YÜCEL: Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Australia; L. F. FONTENELLE: Institute of Psychiatry, Federal University of Rio de Janeiro, Institute of Community Health, Fluminense Federal University, and D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil

Dr. Fontenelle is currently receiving grant #303846/2008-9 from Conselho Nacional de Desenvolvimento Científico e Tecnológico and grant #E-26/103.252/2011 from Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Dr. Yücel is currently receiving a National Health and Medical Research Council of Australia Grant #1021973.

Please send correspondence to: Leonardo F. Fontenelle, Rua Vencesláu Brás 71 fundos, Botafogo, Rio de Janeiro, Brazil.

© 2013 Lippincott Williams & Wilkins, Inc.