ARTICLESPersistent Cognitive Dysfunction Despite Clinical Improvement in Schizophrenia A 10-Year Follow-up StudyShrivastava, Amresh MD, DPM, MRCPsych*; Johnston, Megan MA†; Shah, Nilesh MD‡; Thakar, Meghana MA§; Stitt, Larry MSc∥Author Information *Mental Health Foundation of India (PRERANA Charitable trust) and Silver Mind Hospital, Mumbai, currently at The University of Western Ontario and Lawson Health Research Institute, London, Canada †University of Toronto ‡LTMG Hospital, University of Mumbai §Silver Mind Hospital, Mumbai, currently at Lambeth CAMHS Early Intervention Team, South London and Maudsley NHS Trust, London ∥The University of Western Ontario, London, Canada Please send correspondence to: Megan Johnston, Department of Psychology, University of Toronto, 100 St. George Street, 4th floor Sidney Smith Hall, Toronto, Ontario, Canada, M5S 3G3. [email protected] The authors declare no conflicts of interest. Journal of Psychiatric Practice: May 2011 - Volume 17 - Issue 3 - p 194-199 doi: 10.1097/01.pra.0000398412.67115.5c Buy Metrics Abstract One negative outcome associated with schizophrenia is a deterioration of cognitive functioning. Little is known about what happens to cognitive abilities in the years following a diagnosis of first-episode schizophrenia. This study assessed the cognitive functioning of 61 individuals with first-episode schizophrenia who showed significant clinical improvement (Clinical Global Improvement rating of much or very much improved) after 10 years of treatment, comparing their cognitive functioning at the time of the initial diagnosis and at 10-year follow-up. Our results indicated deterioration in some cognitive abilities at baseline with further decline in this area found after 10 years. Visuomotor integration, working memory, and executive functioning deteriorated in the 10 years of treatment following diagnosis, and many individuals who were classified as much or very much improved still demonstrated abnormal cognitive functioning. These findings suggest the need for greater focus on cognitive functioning in treatment for schizophrenia. Copyright © 2011 Wolters Kluwer Health, Inc. All rights reserved.