Original ArticlesThree-Dimensional–Printed Laboratory-on-a-Chip With Microelectronics and Silicon IntegrationThomas, Daniel J. EngD*; McCall, Caitlin MEng†; Tehrani, Zari PhD†; Claypole, Tim C. PhD†Author Information From the *Yale School of Engineering and Applied Science, Yale University, New Haven, CT; and †College of Engineering, Swansea University, Swansea, UK. Reprints: Daniel J. Thomas, EngD, Yale School of Engineering and Applied Science, Yale University, 10 Hillhouse Ave, New Haven, CT. E-mail: firstname.lastname@example.org. The authors declare no conflict of interest. Point of Care: The Journal of Near-Patient Testing & Technology: June 2017 - Volume 16 - Issue 2 - p 97-101 doi: 10.1097/POC.0000000000000132 Buy Metrics Abstract In this research, an integrated three-dimensional (3D)–printed laboratory-on-a-chip system was developed based on integrating conventional silicon biosensing systems with silver screen–printed electronics. It was discovered that by integrating 220-μm width microchannels, fabricated using 3D-printed polymers, it would offer a means for the development of a microfluidic device with the further possibility for electrically integrating different elements through depositing screen-printed silver contacts. The objective was to achieve low resistance and high reliability with low cost for manufacturing 3D-printed point-of-care diagnostic devices. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.