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An Evaluation of the Point-of-Care Test i-CHROMA Prostate-Specific Antigen Method for Screening in the Community

Bolodeoku, John DPhil (Oxon), FRCPath*; Bains, Suman MSc*; Chand, Vivek MRPharms, BPharm; Bacon, Roger John; Weir, Peter§; Miles, Vivian MBA; Chinegwundoh, Frank MD, FRCS

Point of Care: The Journal of Near-Patient Testing & Technology: June 2017 - Volume 16 - Issue 2 - p 93–96
doi: 10.1097/POC.0000000000000131
Original Articles

Background This study evaluated and compared the performance of the i-CHROMA point-of-care testing (POCT) method for the quantification of prostate-specific antigen (PSA) against a traditional laboratory PSA method (Abbott Architect assay).

Materials and Method Blood samples (venous [143] serum [143]) and finger prick (55) were collected from volunteers at a PSA screening campaign. Both venous and finger-prick samples were analyzed using the i-CHROMA PSA method and serum samples using the Abbott Architect method. Results were compared using linear regression and Red Amber Green analysis, a scoring system based on volunteer's age and PSA level. Red indicated a raised PSA, amber indicated a slightly raised PSA, and green indicated a normal PSA.

Results The data showed that both the i-CHROMA PSA results using the venous samples (r 2 = 0.9841) and the finger-prick samples (r 2 = 0.90845) showed a good correlation when compared with the serum samples using the laboratory method. The Red Amber Green analysis showed the i-CHROMA' venous PSA method identified 15 reds, 13 ambers, and 115 greens compared with 9 reds, 8 ambers, and 126 greens identified by Abbot Architect method. The i-CHROMA finger-prick PSA method identified 3 reds, 3 ambers, and 49 greens compared with 3 reds, 1 ambers, and 51 greens identified by Abbot Architect method.

Conclusions The i-CHROMA POCT PSA method showed good correlation with the Abbott Architect PSA method. Higher numbers of raised and abnormal PSA were identified by the i-CHROMA POCT PSA method due to the positive bias observed. The i-CHROMA POCT PSA method is a reliable method for total PSA within its limitations.

From the *JB Consulting MDP Research Laboratory Cherwell Innovation Centre, Oxfordshire; †Independent Consultant (Vekindo Lmt) 28, Middlesex; ‡Prostate Cancer Support Organisation, West Sussex; §Institute Biomedical Sciences, Southampton; ∥Kitsons, West Sussex; and ¶School of Health Sciences, City, University of London, London, UK.

Reprints: John Bolodeoku, DPhil (Oxon), FRCPath, JB Consulting MDP Research Laboratory Cherwell Innovation Centre, 77 Heyford Park, Upper Heyford, Oxfordshire, OX25 5HD 01628 421735. E-mail: john.bolodeoku@jbconsultingmdp.com.

The authors declare no conflict of interest.

JB Consulting (MDP) is the UK distributor for Boditech Med Inc, the manufacturer of the i-CHROMA system.

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved