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Investigation of Falsely Decreased Creatinine Results Observed From the Abbott I-STAT Point-of-Care Device in Use for Testing Specimens From Ambulatory Oncology Patients

Bahar, Burak MD; DeChristopher, Phillip J. MD, PhD; Holmes, Earle W. PhD; Kahn, Stephen E. PhD

Point of Care: The Journal of Near-Patient Testing & Technology: June 2016 - Volume 15 - Issue 2 - p 72–77
doi: 10.1097/POC.0000000000000093
Original Articles

The goals of this study were to assess the use of the I-STAT for blood creatinine measurement in oncology patients and to determine whether chemotherapy or other factors contributed to the discrepant point-of-care creatinine test results observed in specimens from patients in ambulatory oncology settings. Our studies led us to consider other possible causes of observed discrepancies beyond the effects of chemotherapeutic drugs, including lot-to-lot variation in I-STAT reagent cartridges.

From the Department of Pathology, Stritch School of Medicine, Loyola University Health System, Health Sciences Division, Loyola University of Chicago, Maywood, IL.

Reprints: Stephen E. Kahn, PhD, Pathology, Clinical Laboratories, Room 0148, Loyola University Health System, 2160 S First Ave, Maywood, IL 60153. E-mail:

The authors declare no conflict of interest.

Research funding was provided by internal research grant from Loyola University Health System Department of Pathology.

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