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A Tale of 2 Studies: How 2 Clinical Trials Changed the Use of Glucose Meters in Healthcare

Karon, Brad S. MD, PhD

doi: 10.1097/POC.0000000000000027
Review Article

Glucosemeters are a fast and convenient way to measure circulating blood glucose. Like many technologies in healthcare, the use of glucose meters within the hospital has evolved significantly during the last few decades. In the case of glucose meters, device use has been propelled by 2 sets of landmark clinical trials: the Diabetes Control and Complications (DCCT) trial published in 1993 and the intensive care unit glycemic control trials starting with the work of Dr Van den Berghe et al in 2001. This review will detail how these landmark studies changed the role of glucose meters in the hospital setting and the controversies and questions opened by the expanded use of glucose meters in the hospital.

From the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Reprints: Brad S. Karon, MD, PhD, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. E-mail:

The author declares no conflict of interest.

© 2014 by Lippincott Williams & Wilkins