Original ArticlesEvaluation of the Lipid Panel on the Abaxis Piccolo Xpress to Determine Its Potential as a Point-of-Care Instrument in a Nonlaboratory SettingSimpson, Paul BSc*; Jolly, Lisa BSc†; Tirimacco, Rosy BSc*; Gill, Jan BSc†; Tideman, Philip MBBS, FRACP*Author Information From the *Integrated Cardiovascular Clinical Network SA, Bedford Park and †RCPA Chemical Pathology Quality Assurance Program, Adelaide, South Australia, Australia. Reprints: Paul Simpson, BSc, iCCnet SA, Level 3B (Mail Box 28) Mark Oliphant Bldg, Laffer Dr, Bedford Park SA 5042, Australia. E-mail: [email protected]. The authors have no conflicts of interest to disclose. Point of Care: The Journal of Near-Patient Testing & Technology: March 2010 - Volume 9 - Issue 1 - p 32-35 doi: 10.1097/POC.0b013e3181d2d8b9 Buy Metrics Abstract Cardiovascular disease is the largest cause of mortality in Australia, accounting for 34% and 39% of male and female deaths, respectively. Hyperlipidemia is a modifiable risk factor for cardiovascular disease. The National Cholesterol Education Program (NCEP) has published recommendations for analytical performance targets for lipid analysis. These guidelines set targets for allowable bias, imprecision, and total analytical error. We evaluated the lipid panel on the Piccolo Xpress point-of-care instrument (Abaxis, Union City, Calif) for the measurement of total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride levels. All 3 tests concurred with NCEP recommendations for bias and total analytical error. Imprecision was acceptable for total cholesterol and triglycerides, but HDL cholesterol exceeded the recommendations. However, this differs from the HDL cholesterol precision analysis performed by Abaxis that produced precision results within the NCEP guidelines. This may better reflect the true imprecision of the Piccolo Xpress owing to the much higher number of replicate tests performed compared with our study, which was limited by the number of disks available. Results of this study suggest that the Abaxis Piccolo Xpress is a suitable point-of-care instrument to use in nonlaboratory settings for lipid analysis. © 2010 Lippincott Williams & Wilkins, Inc.