Original ArticlesEvaluation of Multiple Whole Blood Glucose Methods Compared With a Laboratory Plasma Hexokinase Reference AssayScott, Renee J. BS; Deobald, Gayle AS; Griesmann, Laurie AS; Wockenfus, Amy M. BS; Karon, Brad S. MD, PhDAuthor Information From the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Figures 1 and 2 can be viewed online in color at http://www.poctjournal.com. Reprints: Brad S. Karon, MD, PhD, Department of Laboratory Medicine andPathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 (e-mail: [email protected]). Point of Care: The Journal of Near-Patient Testing & Technology: June 2008 - Volume 7 - Issue 2 - p 43-46 doi: 10.1097/POC.0b013e31817278f2 Buy Metrics Abstract We evaluated the accuracy of multiple point-of-care devices used for glucose determination in hospital inpatients compared with a plasma hexokinase reference method. The point-of-care whole blood glucose methods included the i-STAT G cartridge (i-STAT Corporation, East Windsor, NJ), Roche Accu-Chek Inform meter (Roche Diagnostics, Indianapolis, Ind), HemoCue β-glucose and HemoCue 201 glucose analyzers (HemoCue, Angelholm, Sweden), and the Radiometer ABL 725 (Radiometer Medical A/S, Copenhagen, Denmark). Plasma glucose on the Integra 400 (Roche Diagnostics) was used as the reference method. The Radiometer and i-STAT displayed the best overall performance as compared with the reference method based on slope, intercept, median bias, and percent values within 10% (for reference values >100 mg/dL) or 10 mg/dL (for reference values ≤100 mg/dL) of the reference method. Both HemoCue β-glucose and Roche Accu-Chek Inform produced more values that exceeded 10% or 10 mg/dL of the reference value compared with Radiometer or i-STAT. The HemoCue 201 produced consistently high glucose values compared with the reference method and demonstrated poor overall performance. © 2008 Lippincott Williams & Wilkins, Inc.