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Clinical and Analytical Performance of the Accu-Chek Inform Point-of-Care Glucose Meter

Brouwers, Annelies PharmD; Bernard, Dirk MD; Langlois, Michel MD, PhD

Point of Care: The Journal of Near-Patient Testing & Technology: March 2005 - Volume 4 - Issue 1 - p 36-40
doi: 10.1097/01.poc.0000157098.59514.86
Symposium Article

In this study, the clinical and analytical performance of the Accu-Chek Inform point-of-care (POC) glucose meter was evaluated in two of our hospital's most critical units (neonatal [NIC] and adult intensive care [IC]). The results of this POC glucose system were compared with those of our reference laboratory methods. The evaluation was carried out on arterial whole-blood samples collected for routine monitoring of glucose and blood gases. At NIC, glucose measurement with the POC system was paralleled by measurement on the same sample by ABL 725 Blood Gas Analyzer. At adult IC, POC values were also compared with whole-blood measurements obtained by the YSI 2300 STAT plus and plasma measurements obtained by the Modular P800. Within- and between-day coefficient of variation determined by repetitive measurements of two levels of commercially available quality-control material ranged from 4.9% to 5.0% and from 4.9% to 6.1%, respectively. Linearity was excellent within the range from 1.7 to 28.4 mmol/L. Passing-Bablok regression analysis showed good correlation between the POC glucometer and reference laboratory methods except for the YSI 2300 STAT plus. Ninety-five percent to 99% of the results compared with the ABL 725 Blood Gas Analyzer and Modular P800 were in agreement with National Committee for Clinical Laboratory Standards (NCCLS) criteria versus only 77% for comparison with the YSI 2300 STAT plus. Analogue results were observed for error grid analysis, where only 82% of the results fell in region A for comparison with YSI 2300 STAT plus versus 94-97% for comparison with other reference laboratory systems.

From the Department of Clinical Chemistry and Haematology, AZ St-Jan AV Hospital, Brugge, Belgium.

Reprints: Dr. Dirk Bernard, Department of Clinical Chemistry and Haematology, AZ St-Jan AV Hospital, Ruddershove 10, B-8000 Brugge, Belgium (e-mail:

© 2005 Lippincott Williams & Wilkins, Inc.