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Magnetic Resonance Imaging Characterization of Orbital Changes with Age and Associated Contributions to Lower Eyelid Prominence

Darcy, Sean J. M.D.; Miller, Timothy A. M.D.; Goldberg, Robert A. M.D.; Villablanca, J Pablo M.D.; Demer, Joseph L. M.D., Ph.D.; Rudkin, George H. M.D.

Plastic and Reconstructive Surgery: September 2008 - Volume 122 - Issue 3 - p 921-929
doi: 10.1097/PRS.0b013e3181811ce8
Cosmetic: Original Articles

Background: Multiple orbital aging models have been suggested to explain the progressive development of lower eyelid prominence. Objective data to support these theories are limited, however.

Methods: Orbital anatomy was measured with high-resolution orbital magnetic resonance imaging in the quasi-sagittal plane parallel to the long axis of the orbit passing through the globe center. The association between measurements and age was analyzed by stratifying subjects into predetermined age groups and as a continuous variable.

Results: Forty subjects (17 men and 23 women) were imaged and are reported by age group: 12 to 29 years, 30 to 54 years, and 55 to 80 years. Inferior periocular soft-tissue area anterior to the anteroposterior globe axis increased with age: 99, 103, and 131 mm2 (p = 0.008), respectively. The largest contributor to this size increase was fat expansion: 28, 31, and 43 mm2 (p = 0.009), respectively. Total orbital fat also increased with age: 335, 377, and 398 mm2, respectively (p = 0.035). The globe position relative to the inferior orbit in both the anteroposterior and the superoinferior planes remained unchanged.

Conclusions: The authors' measurements suggest that with aging there is a significant increase in anterior inferior periocular soft-tissue volume, and that fat expansion is the main contributor to this volume increase. These observations provide supporting evidence that orbital fat expansion occurs with age and is the primary age-associated contributor to lower eyelid prominence, rather than globe descent or fat repositioning caused by weakening of the orbital septum. We believe these data suggest that fat excision should be a component of treatment for lower eyelid prominence.

Los Angeles, Calif.

From the David Geffen School of Medicine, the Division of Plastic and Reconstructive Surgery, Department of Surgery, the Division of Orbital and Ophthalmic Plastic Surgery, the Department of Ophthalmology, the Department of Neurology, Neuroscience and Bioengineering Interdepartmental Programs, Jules Stein Eye Institute, and the Section of Neuroradiology, Department of Radiological Science, University of California, Los Angeles.

Received for publication October 17, 2007; accepted March 3, 2008.

Presented at the Annual Conference of the Southern California Chapter of the American College of Surgeons, in Santa Barbara, California, on January 21, 2007; at the American Association of Plastic Surgeons Meeting, in Coeur d'Alene, Idaho, on May 22, 2007; and at the California Society of Plastic Surgeons Meeting, in San Francisco, California, on May 25, 2007.

Disclosure: None of the authors has any commercial associations or financial relationships that might pose or create a conflict of interest with information presented in this article.

George H. Rudkin, M.D., Division of Plastic and Reconstructive Surgery, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 200 UCLA Medical Plaza, Suite 465, Los Angeles, Calif. 90095, grudkin@mednet.ucla.edu

©2008American Society of Plastic Surgeons