PRSonally Speaking

Wednesday, May 4, 2011

Articles of Interest Sneak Peak: Breast fat grafting with platelet-rich plasma: a comparative clinical study and current state of art
At least twice a month, PRSonally Speaking posts full abstracts of interesting or potentially controversial articles from a future issue. This 'sneak preview' of a hot article is meant to give you some food for thought and provide you with topic for conversation among colleagues.
When the article is published in print, it will be Open Access for a period of Two Months, to help the conversation continue in the PRS community and beyond. So read the abstract, join the conversation and spread the word.
This week we present the abstract of "Breast fat grafting with platelet-rich plasma: a comparative clinical study and current state of art" by Marzia Salgarello, M.D.; Giuseppe Visconti, M.D.; Antonio Rusciani, M.D., Ph.D.  
Background:   The role of Platelet-Rich Plasma (PRP) in enhancing fat grafts take is attracting the scientific community. However, there is a lack of clinical series on the matter.

The aim of this paper is to report Authors' experience in breast fat graft with and without PRP and to investigate the state-of-art on adipose tissue PRP enrichment.

Methods: The Authors retrospectively reviewed forty-two women, which underwent breast fat graft between September 2007 and September 2009. Among these, 17 patients (40%) were grafted with fat according to Coleman enriched with PRP at 10% (Group A), and 25 cases (60%) received only fat graft according to Coleman (Group B). All patients underwent preoperative breast ultrasound (US) and mammography and were regularly followed-up with breast US 3 months later and then at 6-months interval.

The reconstructive and aesthetic outcomes were evaluated referring to the following parameters: 1) clinical outcomes according to the surgeons and the patient; 2) the rate of liponecrosis at breast US and 3) the needing of further fat graft to achieve the planned result.

Results: The clinical outcomes, the rate of liponecrosis at breast US and the needing of further fat graft reveals that fat graft plus PRP at 10% is not superior to Coleman fat graft alone.

Conclusion: In Authors' retrospective analysis no effect of PRP was seen in enhancing fat graft take when compared to Coleman fat graft. Further research and prospective clinical studies are strongly needed to understand the role of PRP, if any, in fat grafting.
Figure 4 from the manuscript:

The patient presented with contour defect after lateral pole quadrantectomy plus radiation therapy. (above) She underwent one session of fat graft without PRP. The scar tissue has been released using a NoKor ® needle.  She received 169 cc of fat. Six months later the patient is not satisfied with the result. (below) She has been classified as grade 2.

The full article will be published with the June 2011 issue of PRS, and will be free online for non-subscribers. Until then, we hope this "sneak peek" will pique your interests and start a healthy, meaningful conversation.