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Breast Cancer Molecular Subtypes and Chemotherapy Schedules Used in Neoadjuvant or Adjuvant Setting May Show Different Effects in Nipple-Sparing Mastectomy

Altundag, Kadri M.D.

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Plastic and Reconstructive Surgery: September 2017 - Volume 140 - Issue 3 - p 495e
doi: 10.1097/PRS.0000000000003609
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I want to congratulate Frey and colleagues on their article in which they explored the effects of neoadjuvant and adjuvant chemotherapy in nipple-sparing mastectomy.1 They found that nipple-sparing mastectomy is safe to perform in the setting of neoadjuvant and adjuvant chemotherapy. Furthermore, the authors reported that neoadjuvant (with or without adjuvant) chemotherapy increases the risk of complications.1 However, the authors did not provide detailed information about the chemotherapy (adjuvant chemotherapy versus adjuvant chemotherapy plus taxanes with or without trastuzumab) schedules, as neoadjuvant and adjuvant chemotherapy that patients receive may impact nipple-sparing mastectomy, and also I did not see any information about the effects of breast tumor subtypes (luminal A or B versus HER2-positive tumors versus triple-negative breast tumors) on nipple-sparing mastectomy. The medical literature did not provide any information about these two issues. If they report this information from patients’ charts, we might acquire new data about the association between tumor subtypes or chemotherapy schedules and nipple-sparing mastectomy.


The author has no financial interest to declare in relation to the content of this communication.

Kadri Altundag, M.D.
MKA Breast Cancer Clinic
Tepe Prime, Cankaya
06800 Ankara, Turkey
[email protected]


1. Frey JD, Choi M, Karp NS. The effect of neoadjuvant chemotherapy compared to adjuvant chemotherapy in healing after nipple-sparing mastectomy. Plast Reconstr Surg. 2017;139:10e19e.


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