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TallyHo Diabetic Phenotype Limited to Male Mice

Female Mice Provide Obese, Nondiabetic Mouse Model

Wagner, Ida Janelle M.D.

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Plastic and Reconstructive Surgery: April 2012 - Volume 129 - Issue 4 - p 727e
doi: 10.1097/PRS.0b013e318245eaff
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Sir:

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A recent article, “The TallyHo Polygenic Mouse Model of Diabetes: Implications in Wound Healing” (Plast Reconstr Surg. 2011;128:427e–437e),1 described the use of the TallyHo/JnJ mouse as a diabetic mouse model. The article does not specify the sex of the TallyHo mice. This is an important distinction because male TallyHo mice are diabetic, whereas female TallyHo mice are not. In our laboratory at New York University Institute of Reconstructive Plastic Surgery, we worked extensively with female TallyHo mice in our wound healing and obesity research specifically because they provide an excellent model of obese mice that are not diabetic—a rare find. Female TallyHo mice provide an ideal mouse model for studying obesity without diabetes. In our laboratory, we have measured average blood glucose levels of 92 ± 23 mg/dl in female TallyHo mice. Interestingly, although blood glucose levels above 200 to 300 mg/dl are generally accepted to define diabetes in a mouse, we have not found literature that specifically defines the blood glucose level required for this diagnosis.

Ida Janelle Wagner, M.D.

Department of Plastic and Reconstructive Surgery, University of North Carolina at Chapel Hill, 7040 Burnett-Womack, CB 7195, Chapel Hill, N.C. 27599

REFERENCE

1. Buck DW II, Jin DP, Geringer M, Hong SJ, Galiano RD, Mustoe TA. The TallyHo polygenic mouse model of diabetes: Implications in wound healing. Plast Reconstr Surg. 2011;128:427e–437e. Epublished ahead of print July 5, 2011.

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