New-Fill has gained a reputation as a safe and reliable product. There are few reports of granuloma formation as a long- or intermediate-term adverse reaction to New-Fill injection.2–4 Late-onset infection of the injection site has not been described.
It is worth noting that all four patients were healthy with no significant medical history apart from heavy smoking. Little is known regarding the relationship between host factors and the development of adverse reactions. We suggest a possible connection between smoking and adverse reactions after New-Fill injections.
Further research is necessary to elucidate the mechanisms that cause late-onset infection and granuloma formation after New-Fill injection. In addition, more data are required to estimate the incidence of these side effects.
O. Goldan, M.D.
G. Garbov-Nardini, M.D.
E. Regev, M.D.
A. Orenstein, M.D.
E. Winkler, M.D.
1. Moyle, G., Brown, S., Lysakova, L., and Barton, S. Long-term safety and efficacy of poly-L-lactic acid in the treatment of HIV-related facial lipoatrophy. HIV Med.
7: 181, 2006.
2. Lombardi, T., Samson, J., Plantier, F., Husson, C., and Kuffer, R. Orofacial granulomas after injection of cosmetic fillers: Histopathologic and clinical study of 11 cases. J. Oral Pathol. Med.
33: 115, 2004.
3. Dijkema, S. J., van der Lei, B., and Kibbelaar, R. E. New-Fill injections may induce late-onset foreign body granulomatous reaction. Plast. Reconstr. Surg.
115: 76e, 2005.
4. Christensen, L., Breiting, V., Janssen, M., Vuust, J., and Hogdall, E. Adverse reactions to injectable soft-tissue permanent fillers. Aesthetic Plast. Surg.
29: 34, 2005.
Viewpoints, pertaining to issues of general interest, are welcome, even if they are not related to items previously published. Viewpoints may present unique techniques, brief technology updates, technical notes, and so on. Viewpoints will be published on a space-available basis because they are typically less timesensitive than Letters and other types of articles. Please note the following criteria:
Authors will be listed in the order in which they appear in the submission. Viewpoints should be submitted electronically via PRS' enkwell, at www.editorialmanager.com/prs/. We strongly encourage authors to submit figures in color.
We reserve the right to edit Viewpoints to meet requirements of space and format. Any financial interests relevant to the content must be disclosed. Submission of a Viewpoint constitutes permission for the American Society of Plastic Surgeons and its licensees and assignees to publish it in the Journal and in any other form or medium.
The views, opinions, and conclusions expressed in the Viewpoints represent the personal opinions of the individual writers and not those of the publisher, the Editorial Board, or the sponsors of the Journal. Any stated views, opinions, and conclusions do not reflect the policy of any of the sponsoring organizations or of the institutions with which the writer is affiliated, and the publisher, the Editorial Board, and the sponsoring organizations assume no responsibility for the content of such correspondence.