As antibiotic resistance increases and antimicrobial options diminish, there is a pressing need to identify and develop new and/or alternative (non–antimicrobial-based) wound therapies. The authors describe the implications of antibiotic resistance on their current wound treatment paradigms and review the most promising non–antibiotic-based antimicrobial agents currently in research and development, with a focus on preclinical and human studies of therapeutic bacteriophages, antimicrobial peptides, cold plasma treatment, photodynamic therapy, honey, silver, and bioelectric dressings.
New York and Ithaca, N.Y.
From the Division of Plastic Surgery, Weill Cornell Medical College; Columbia University College of Physicians and Surgeons; and the Meinig School of Biomedical Engineering, Cornell University.
Received for publication September 24, 2017; accepted March 16, 2018.
Disclosure:The authors have no financial interest to declare in relation to the content of this article.
Jason A. Spector, M.D., Weill Cornell Medical College, 525 East 68th Street, Payson 709-A, New York, N.Y. 10065, firstname.lastname@example.org