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How to Diagnose and Treat Breast Implant–Associated Anaplastic Large Cell Lymphoma

Clemens, Mark W., M.D.; Brody, Garry S., M.D.; Mahabir, Raman C., M.D.; Miranda, Roberto N., M.D.

Plastic and Reconstructive Surgery: April 2018 - Volume 141 - Issue 4 - p 586e-599e
doi: 10.1097/PRS.0000000000004262

Learning Objectives: After reading this article, the participant should be able to: 1. Describe the diagnostic criteria for breast implant–associated (BIA) anaplastic large cell lymphoma (ALCL). 2. Appropriately evaluate a patient with suspected BIA-ALCL, including appropriate imaging, laboratory tests, and pathologic evaluation. 3. Understand the operative treatment of BIA-ALCL, and indications for systemic chemotherapy and/or radiation therapy in advanced disease. 4. Understand treatment outcomes and prognosis based on stage of disease.

Summary: The goal of this continuing medical education module is to present the assessment of a patient with suspected breast implant–associated anaplastic large cell lymphoma, the evaluation and diagnosis, the preoperative oncologic workup, the formation and execution of a surgical treatment plan, and the inclusion of adjunct treatments when indicated. In addition, staging and disease progression for treatment of breast implant–associated anaplastic large cell lymphoma are discussed.

Houston, Texas; Los Angeles, Calif.; and Scottsdale, Ariz.

From the Departments of Plastic Surgery and Hematopathology, M. D. Anderson Cancer Center; the Department of Plastic Surgery, Keck School of Medicine, University of Southern California; and the Department of Plastic Surgery, Mayo Clinic.

Received for publication September 11, 2017; accepted November 10, 2017.

Disclosure:None of the authors has any relevant financial relationships or affiliations to disclose.

Mark W. Clemens, M.D., Department of Plastic Surgery, M. D. Anderson Cancer Center, 1400 Pressler Street, Unit 1488, Houston, Texas 77030,

Copyright © 2018 by the American Society of Plastic Surgeons