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Evidence-Based Medicine: Nonsyndromic Craniosynostosis

Tahiri, Youssef M.D., C.M., M.Sc.; Bartlett, Scott P. M.D.; Gilardino, Mirko S. M.D., M.Sc.

Plastic and Reconstructive Surgery: July 2017 - Volume 140 - Issue 1 - p 177e-191e
doi: 10.1097/PRS.0000000000003473
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Learning Objectives: After reading this article, the participant should be able to: 1. Understand the craniofacial dysmorphology associated with nonsyndromic craniosynostosis. 2. Understand the functional concerns and preoperative considerations when treating patients with nonsyndromic craniosynostosis. 3. Understand the various treatment options available to address patients with nonsyndromic craniosynostosis. 4. Recognize the current debate with regard to timing and type of surgical intervention, and their impact on patient outcome, for patients with nonsyndromic craniosynostosis.

Summary: Craniosynostosis is a pathologic condition associated with the premature fusion of one or more cranial sutures. When the cranial sutures fuse prematurely, the skull and the growing brain beneath the suture are restricted, leading to a compensatory expansion into regions of the skull that are not affected. Craniosynostosis can occur in isolation (nonsyndromic) or can be associated with other extracranial anomalies. When anomalies outside the skull are present, craniosynostosis is often part of a syndrome and usually involves multiple sutures (syndromic craniosynostosis). This article focuses on nonsyndromic craniosynostosis, and describes the current state of knowledge regarding its diagnosis, surgical management, and outcomes.

Indianapolis, Ind.; Philadelphia, Pa.; and Montreal, Quebec, Canada

From the Department of Plastic and Reconstructive Surgery at Cedars Sinai Medical Center; the Division of Plastic Surgery, Perelman School of Medicine at the University of Pennsylvania, Children’s Hospital of Philadelphia; and the Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montreal Children’s Hospital.

Received for publication February 8, 2016; accepted April 19, 2016.

Disclosure:The authors have no financial disclosures to report. No funding was received for this article.

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Mirko S. Gilardino, M.D., M.Sc., F.R.C.S.C., F.A.C.S., Montreal Children's Hospital, Division of Plastic & Reconstructive Surgery, McGill University Health Centre, 1001 Decarie Boulevard, B05.3310 Montreal, Canada H4A 3J1

Copyright © 2017 by the American Society of Plastic Surgeons