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Purified Adipose-Derived Stromal Cells Provide Superior Fat Graft Retention Compared with Unenriched Stromal Vascular Fraction

Zielins, Elizabeth R. M.D.; Brett, Elizabeth A. M.S.; Blackshear, Charles P. M.D.; Flacco, John B.S.; Ransom, Ryan C. B.A.; Longaker, Michael T. M.D., M.B.A.; Wan, Derrick C. M.D.

Plastic and Reconstructive Surgery: April 2017 - Volume 139 - Issue 4 - p 911–914
doi: 10.1097/PRS.0000000000003165
Experimental: Ideas and Innovations

Summary: Cell-assisted lipotransfer has shown much promise as a technique to improve fat graft retention in both mouse and human studies. However, the literature varies as to whether fresh stromal vascular fraction or culture-expanded adipose-derived stromal cells are used to augment volume retention. The authors’ study sought to determine whether there was a significant advantage to using adipose-derived stromal cells over unpurified stromal vascular fraction cells in a mouse model of cell-assisted lipotransfer.

Stanford, Calif.

From the Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, and the Institute for Stem Cell Biology and Regenerative Medicine, Stanford University.

Received for publication March 10, 2016; accepted August 22, 2016.

Disclosure: The authors have no financial interest to declare in relation to the content of this article.

Derrick C. Wan, M.D., Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, 257 Campus Drive, Stanford, Calif. 94305-5148,

©2017American Society of Plastic Surgeons