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Laboratory Models for the Study of Normal and Pathologic Wound Healing

Boyko, Tatiana V. M.D.; Longaker, Michael T. M.D., M.B.A.; Yang, George P. M.D., Ph.D.

Plastic and Reconstructive Surgery: March 2017 - Volume 139 - Issue 3 - p 654–662
doi: 10.1097/PRS.0000000000003077
Experimental: Special Topic

Summary: Current knowledge of wound healing is based on studies using various in vitro and in vivo wound models. In vitro models allow for biological examination of specific cell types involved in wound healing. In vivo models generally provide the full spectrum of biological responses required for wound healing, including inflammation and angiogenesis, and provide cell-cell interactions not seen in vitro. In this review, the authors aim to delineate the most relevant wound healing models currently available and to discuss their strengths and limitations in their approximation of the human wound healing processes to aid scientists in choosing the most appropriate wound healing models for designing, testing, and validating their experiments.

Stanford and Palo Alto, Calif.; and Buffalo, N.Y.

From the Hagey Laboratory for Pediatric Regenerative Medicine, the Department of Surgery, and the Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; the Palo Alto VA Health Care System; and the Department of Surgery, University at Buffalo, State University of New York.

Received for publication May 4, 2016; accepted July 13, 2016.

Disclosure: The authors have no financial interest to disclose in relation to the content of this article.

George P. Yang, M.D., Ph.D., 257 Campus Drive, Stanford, Calif. 94305,

©2017American Society of Plastic Surgeons