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Wound Healing: Part I. Basic Science

Janis, Jeffrey E. MD; Harrison, Bridget MD

Plastic and Reconstructive Surgery: September 2016 - Volume 138 - Issue 3S - p 9S-17S
doi: 10.1097/PRS.0000000000002773
Original Articles

Learning Objectives: After studying this article, the participant should be able to: 1. Describe the basic physiologic events in normal wound healing. 2. Understand the differences in healing among skin, bone, cartilage, and tendon. 3. Identify factors that may compromise or delay wound healing. 4. Describe methods for optimal closure of a wound.

Summary: Understanding the physiology and pathophysiology of normal wound healing and potential impediments to its end will allow the plastic surgeon to maximize postoperative outcomes and, in some instances, avoid unnecessary surgical interventions. Continuous advancements in our understanding of this process require frequent reviews of available data to permit reliable, evidence-based recommendations for clinical application. This is the first of a two-part article summarizing the science and clinical recommendations necessary for successful wound healing.

Colombus, Ohio; and Dallas, Texas

From the Department of Plastic Surgery, Ohio State University Medical Center; and Department of Plastic Surgery, University of Texas Southwestern Medical Center.

Republished from Plast Reconstr Surg. 133:199e–207e, 2014.

Received for publication February 3, 2013; accepted April 16, 2013.

Disclosure:Dr. Janis is a member of the advisory board for Integra LifeSciences and a consultant for LifeCell. Dr. Harrison has no financial disclosures.

Jeffrey E. Janis, M.D., Department of Plastic Surgery, Ohio State University, Wexner Medical Center, 915 Olentangy River Road, Suite 2100, Room 2114, Columbus, Ohio 43212,

Copyright © 2016 by the American Society of Plastic Surgeons