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Regenerative Biomaterials: A Review

Banyard, Derek A. M.D., M.B.A.; Bourgeois, Jenna Martin M.D.; Widgerow, Alan D. M.B.B.Ch., M.Med.; Evans, Gregory R. D. M.D.

Plastic and Reconstructive Surgery: June 2015 - Volume 135 - Issue 6 - p 1740–1748
doi: 10.1097/PRS.0000000000001272
Special Topics: Regenerative Medicine
Video Discussion

Summary: The authors present a review of biomaterials, substances traditionally derived from human or animal tissue or, more recently, biodegradable synthetics modeled after naturally occurring resources. These constructs differ from purely synthetic materials in that they are degraded or incorporated into a host’s tissue. These biomaterials include a diverse array of medical products, such as acellular dermal matrix, bone substitutes, and injectables. In this review, the authors examine various clinical applications, including burn reconstruction and wound healing, breast surgery, complex abdominal wall reconstruction, craniofacial repair, and cosmetic surgery. Biomaterials such as acellular dermal matrix have proven beneficial in difficult-to-treat applications; however, more prospective data are needed to determine their true efficacy and cost-effectiveness.

Video Discussion by Geoffrey C. Gurtner, M.D., is available online for this article.

Orange, Calif.

From the Center for Tissue Engineering, Department of Plastic Surgery, University of California, Irvine.

Received for publication May 21, 2014; accepted December 16, 2014.

Disclosure: The authors have no financial interest to declare in relation to the content of this article.

A Video Discussion by Geoffrey C. Gurtner, M.D., accompanies this article. Go to and click on “Video Discussions” in the “Videos” tab to watch.

Gregory R. D. Evans, M.D., Department of Plastic Surgery, University of California, Irvine, 200 South Manchester Avenue, Suite 650, Orange, Calif. 92868-3224,

©2015American Society of Plastic Surgeons