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Desmopressin as a Hemostatic Agent to Provide a Dry Intraoperative Field in Rhinoplasty

Gruber, Ronald P. M.D.; Zeidler, Kamakshi R. M.D.; Berkowitz, R. Laurence M.D.

Plastic and Reconstructive Surgery: May 2015 - Volume 135 - Issue 5 - p 1337–1340
doi: 10.1097/PRS.0000000000001158
Cosmetic: Original Articles
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Background: Intraoperative bleeding during rhinoplasty makes it difficult to sculpt cartilages. Residual blood from a wet field can lead to induration, fibrosis, and definition loss. Recent studies with desmopressin (1-deamino-8-D-arginine vasopressin) to reduce blood loss in a variety of operations and minimize postoperative bleeding problems suggest using that drug routinely for elective rhinoplasty and not just for patients with coagulation issues.

Method: Seventy-three consecutive rhinoplasty patients received desmopressin for the purpose of obtaining a dry operative field. The initial dose was 0.1 μg/kg. If the field was not as dry as desired, a second dose was given; if necessary, a third dose to a maximum of 0.3 μg/kg was given. All cases exhibited a satisfactorily dry field. There were no adverse effects. A retrospective comparison was made to 300 consecutive cases not receiving desmopressin.

Results: Thirty of the 73 patients received a starting dose of 0.1 μg/kg and nothing more. Fourteen received a second dose of 0.1 μg/kg because the field was not as dry as desired and 29 received a third dose of 0.1 μg/kg because the field was not as dry as desired. All 73 patients exhibited a satisfactorily dry field, in contrast to 9 percent in the group not receiving desmopressin.

Conclusions: This study confirms the hemostatic effectiveness of desmopressin at lower than normally used doses in rhinoplasty. It also confirms its safety. It suggests its use in other procedures. A larger, carefully controlled study is indicated.

CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.

San Francisco, Calif. and Stanford, Calif.

From the University of California, San Francisco; and Stanford University.

Received for publication September 11, 2014; accepted November 3, 2014.

Disclosure: None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this article.

Ronald P. Gruber, M.D., 3318 Elm Street, Oakland, Calif. 94609, rgrubermd@hotmail.com

©2015American Society of Plastic Surgeons