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Antimicrobial Activity of Clinically Used Antiseptics and Wound Irrigating Agents in Combination with Wound Dressings

Hirsch, Tobias M.D.; Limoochi-Deli, Simin M.S.; Lahmer, Armin M.D.; Jacobsen, Frank Ph.D.; Goertz, Ole M.D.; Steinau, Hans-Ulrich M.D.; Seipp, Hans-Martin M.D., Ph.D.; Steinstraesser, Lars M.D.

Plastic and Reconstructive Surgery: April 2011 - Volume 127 - Issue 4 - p 1539-1545
doi: 10.1097/PRS.0b013e318208d00f
Reconstructive: Trunk: Original Articles

Background: A primary strategy for preventing and treating wound infection in chronic wounds is the use of topical antiseptics and wound irrigating agents. However, their interaction with commonly used wound dressings has not yet been investigated. In this study, the authors analyzed the antimicrobial activity of antiseptics and wound irrigating agents used with commercially available wound dressings.

Methods: Five clinically used antiseptics and wound irrigating agents (Prontosan, Lavasept, Braunol, Octenisept, and Betaisodona) were tested in the presence or absence of 42 wound dressings against Staphylococcus aureus. The determination of antibacterial activity was performed by disk diffusion assay.

Results: Povidone-iodine–based products showed sufficient antimicrobial activity in 64 to 78 percent of the combinations assessed (p > 0.01). The octenidine derivate Octenisept showed sufficient antimicrobial activity in 54 percent of combinations. Polyhexamethylene biguanide derivatives demonstrated sufficient antimicrobial activity in 32 percent of the combinations.

Conclusion: This study revealed that commonly used wound dressings dramatically reduce antibacterial activity of clinically used antiseptics and wound irrigating agents in vitro.

Bochum and Giessen, Germany

From the Department of Plastic Surgery, Ruhr-University Bochum, and the Department of Environmental Engineering and Biotechnology, Fachhochschule Giessen-Friedberg.

Received for publication June 1, 2010; accepted October 26, 2010.

Disclosure:This study was funded in part by B. Braun Melsungen AG, Melsungen, Germany.

Lars Steinstraesser, M.D., Department of Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Buerkle-de-la Camp Platz 1, 44789 Bochum, Germany,

©2011American Society of Plastic Surgeons