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The Role of Stem Cells in Cutaneous Wound Healing: What Do We Really Know?

Ko, Sae Hee M.D.; Nauta, Allison M.D.; Wong, Victor M.D.; Glotzbach, Jason M.D.; Gurtner, Geoffrey C. M.D.; Longaker, Michael T. M.D., M.B.A.

Plastic and Reconstructive Surgery: January 2011 - Volume 127 - Issue - p 10S-20S
doi: 10.1097/PRS.0b013e3181fbe2d8
Wound-Healing Supplement: Original Articles

Summary: Wound repair is a complex process involving the orchestrated interaction of multiple growth factors, cytokines, chemokines, and cell types. Dysregulation of this process leads to problems such as excessive healing in the form of keloids and hypertrophic scars and chronic, nonhealing wounds. These issues have broad global implications. Stem cells offer enormous potential for enhancing tissue repair and regeneration following injury. The rapidly developing fields of stem cell biology and skin tissue engineering create translational opportunities for the development of novel stem cell–based wound-healing therapies.

Stanford, Calif.; Washington, D.C.; Pittsburgh, Pa.; Portland, Ore.; and Chapel Hill, N.C.

From the Hagey Laboratory for Pediatric and Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, and the Departments of Surgery of Georgetown University Hospital, University of Pittsburgh Medical Center, University of Oregon Medical Center, and University of North Carolina at Chapel Hill.

Received for publication April 23, 2010; accepted July 10, 2010.

The first two authors contributed equally to this work.

Disclosure: The authors have no financial interest in any of the products, devices, or drugs mentioned in this article.

Michael T. Longaker, M.D., M.B.A.; 257 Campus Drive; Stanford, Calif. 94305-5148;

©2011American Society of Plastic Surgeons