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Treatment of Diabetic Foot Ulcers Using a Blood Bank Platelet Concentrate

Jeong, Seong-Ho M.D.; Han, Seung-Kyu M.D., Ph.D.; Kim, Woo-Kyung M.D., Ph.D.

Plastic and Reconstructive Surgery: March 2010 - Volume 125 - Issue 3 - p 944-952
doi: 10.1097/PRS.0b013e3181cb6589
Reconstructive: Lower Extremity: Original Articles

Background: Many clinical trials have shown the effectiveness of platelet releasate on chronic wound healing, but large volumes of blood must be aspirated from patients and a platelet separator is required. Moreover, in the case of using homologous platelets, time and effort are needed to locate a suitable donor, and the donor's blood sample must be tested for a history of infectious disease. The current study was undertaken to evaluate the effect of a straightforward method using a blood bank platelet concentrate in treating diabetic foot ulcers.

Methods: Fifty-two patients with diabetic foot ulcers were treated using a blood bank platelet concentrate. A control treatment (i.e., treatment with topical fibrinogen and thrombin) was performed on 48 patients. Twelve weeks after treatment, the percentage of complete healing, mean healing time, percentage of wound shrinkage, and patient satisfaction were compared.

Results: Complete wound healing was achieved in 79 percent of the blood bank platelet concentrate–treated group and 46 percent of the control group (p < 0.05). The times required for complete healing were 7.0 ± 1.9 and 9.2 ± 2.2 weeks in the blood bank platelet concentrate–treated and control groups, respectively (p < 0.05). The degrees of wound shrinkage were 96.3 ± 7.8 and 81.6 ± 19.7 percent for the treated and control groups, respectively (p < 0.05). Patient satisfaction with the blood bank platelet concentrate treatment yielded better results than the control method (mean score, 7.6 ± 1.6 and 5.3 ± 1.4, respectively; p < 0.05). No adverse events related to the study treatment occurred.

Conclusions: Treatment of diabetic foot ulcers using a blood bank platelet concentrate showed results superior to control treatment. A blood bank platelet concentrate offers a simple and effective treatment for diabetic foot ulcers.

Seoul, Korea

From the Department of Plastic Surgery, Korea University College of Medicine.

Received for publication August 25, 2009; accepted October 1, 2009.

Presented at the 61st Annual Meeting of the Canadian Society of Plastic Surgeons, in Banff, Alberta, Canada, May 30 through June 2, 2007, and at the 37th Annual Meeting of the Japanese Society for Wound Healing, in Yokohama, Japan, December 6 through 7, 2007.

Disclosure: None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this article.

Seung-Kyu Han, M.D.; Department of Plastic Surgery; Korea University Guro Hospital; 97 Guro-Dong, Guro-Ku; Seoul, Korea 152-703;

©2010American Society of Plastic Surgeons